New research identifies gene that hides cancer cells from immunotherapy

23-Jul-2019 - A team at Fred Hutchinson Cancer Research Center has identified a gene that could make immunotherapy treatments, specifically checkpoint inhibitors, work for a wider variety of cancer patients. The study, published in Developmental Cell, found that when the DUX4 gene is expressed in cancer cells, ...

Researchers identify a new mode of drug resistance to emerging therapies in prostate cancer

19-Nov-2015 - Advanced prostate cancer is a disease notoriously resistant to treatment. New research by scientists at Fred Hutchinson Cancer Research Center and the University of California, San Francisco sheds light on a new mode of drug resistance to emerging therapies in metastatic prostate cancer. This ...

Study finds HIV 'superinfection' boosts immune response

Findings may provide insight into HIV-vaccine development

02-Apr-2012 - Women who have been infected by two different strains of HIV from two different sexual partners – a condition known as HIV superinfection – have more potent antibody responses that block the replication of the virus compared to women who've only been infected once. These findings, by researchers ...

Study of biomarker development in mice provides a roadmap for a similar approach in humans

21-Jun-2011 - Researchers at Fred Hutchinson Cancer Research Center have demonstrated in mice that the performance of a novel biomarker-development pipeline using targeted mass spectrometry is robust enough to support the use of an analogous approach in humans. The findings, by principal investigator Amanda ...

A decade of refinements in marrow and stem cell transplantation improves long-term survival of blood cancers

30-Nov-2010 - A decade of refinements in marrow and stem cell transplantation to treat blood cancers significantly reduced the risk of treatment-related complications and death, according to an institutional self-analysis of transplant-patient outcomes conducted at Fred Hutchinson Cancer Research ...

Radiation exposure poses similar risk of first and second cancers in atomic bomb survivors

First large-scale study to assess how radiation influences risk of multiple cancers

16-Sep-2010 - It is well known that exposure to radiation has multiple harmful effects – including causing cancer – but until now, it has been unclear to what extent such exposure increases a person's risk of developing more than one cancer. The first large-scale study of the relationship between radiation ...

Two Hutchinson Center researchers receive prestigious awards from Damon Runyon Cancer Research Foundation

Drs. Brian Till and Colleen Delaney will use the awards for immunotherapy research

05-Jul-2010 - Two Fred Hutchinson Cancer Research Center researchers who study immunotherapy have received prestigious awards from the Damon Runyon Cancer Research Foundation. Brian Till, M.D., a research associate in the Hutchinson Center's Clinical Research Division, was awarded a three-year, $450,000 ...

First successful use of expanded umbilical-cord blood units to treat leukemia

20-Jan-2010 - Scientists at Fred Hutchinson Cancer Research Center have cleared a major technical hurdle to making umbilical-cord-blood transplants a more widely-used method for treating leukemia and other blood cancers. In a study published in Nature Medicine , Colleen Delaney, M.D., and colleagues describe ...

First use of antibody and stem cell transplantation to successfully treat advanced leukemia

09-Nov-2009 - For the first time, researchers at Fred Hutchinson Cancer Research Center have reported the use of a radiolabeled antibody to deliver targeted doses of radiation, followed by a stem cell transplant, to successfully treat a group of leukemia and pre-leukemia patients for whom there previously had ...

A solution to Darwin's 'mystery of the mysteries' emerges from the dark matter of the genome

28-Oct-2009 - Biological species are often defined on the basis of reproductive isolation. Ever since Darwin pointed out his difficulty in explaining why crosses between two species often yield sterile or inviable progeny (for instance, mules emerging from a cross between a horse and a donkey), biologists have ...