Testing how well biomarkers work

Researchers have developed a method to determine how reliably target proteins can be labeled using super-resolution fluorescence microscopy

02-May-2024 - Modern microscopy techniques make it possible to examine the inner workings of cells in astonishing detail. “We can now observe the arrangement and interaction of individual proteins under the microscope,” says Professor Ralf Jungmann, Chair of Molecular Physics of Life at LMU and Max Planck ...

Microscopy: Overcoming the traditional resolution limit for the fast co-tracking of molecules

Researchers have developed an innovative method to simultaneously track rapid dynamic processes of multiple molecules at the molecular scale

16-Feb-2024 - Processes within our bodies are characterized by the interplay of various biomolecules such as proteins and DNA. These processes occur on a scale often within a range of just a few nanometers. Consequently, they cannot be observed with fluorescence microscopy, which has a resolution limit of ...

Biologists make living sperm glow

16-Jan-2020 - By applying a novel method, biologists at TU Dresden have successfully analysed the metabolism of intact tissues of the fruit fly using a label-free microscopy technique. They used the natural fluorescence of certain metabolic molecules and found that sperm, compared to other tissues, are highly ...

Measuring the Nanoworld

Researchers establish a benchmark for accurate determination of internal dimensions within individual molecules

05-Sep-2018 - A worldwide study involving 20 laboratories has established and standardized a method to measure exact distances within individual biomolecules, down to the scale of one millionth of the width of a human hair. The new method represents a major improvement of a technology called single-molecule ...

The 2011 Körber Prize goes to Stefan Hell

With a groundbreaking idea the physicist has overcome the diffraction resolution barrier in optical microscopy

08-Jul-2011 - Prof. Dr. Dr. h. c. Stefan Hell of the Max Planck Institute for Biophysical Chemistry in Göttingen is to receive the 2011 Körber European Science Prize endowed with 750,000 euros for his pioneering discoveries in the field of optics. Every year, the Körber Prize is awarded to an outstanding ...