“Dictionaries” make fluorescence-based data for integrative structure models and their dynamics accessible

3D structures of biomolecules

23-Oct-2024 - A research team from Germany and the USA led by Heinrich Heine University Düsseldorf (HHU) has developed a data description that can provide results from fluorescence measurements for structural and dynamic modelling of large biomolecules. The authors explain in the scientific journal Nature ...

Cellphone converts into powerful chemical detector

With only $50 worth of components, an ordinary cellphone transforms into a sophisticated scientific instrument, capable of identifying chemicals, drugs, and pathogens

07-May-2021 - Scientists from Texas A&M have developed an extension to an ordinary cellphone that turns it into an instrument capable of detecting chemicals, drugs, biological molecules, and pathogens. The advance is reported in Reviews of Scientific Instruments, by AIP Publishing. Modern cellphones include ...

Enzyme prisons

A team at the MDC has answered a question that has puzzled scientists for some 40 years

28-Aug-2020 - In the journal Cell, the group explains how cells are able to switch on completely different signaling pathways using only one signaling molecule: the nucleotide cAMP. To achieve this, the molecule is virtually imprisoned in nanometer-sized spaces. There are up to a hundred different receptors on ...

Malaria pathogens under the X-ray microscope

X-ray microscopy at BESSY II reveals how antimalaria-drugs might work

04-Nov-2019 - Malaria is one of the most threatening infectious diseases in the world. An international team has now been able to investigate malaria pathogens in red blood cells in vivo using the BESSY II X-ray microscope and the ALBA and ESRF synchrotron sources. The scientists reveal the mechanisms used by ...

The Interior of a Cell from a Moving Protein’s Point of View

Scientists develop new methods to measure intracellular protein movement

13-Aug-2014 - Numerous obstacles posed by cellular structures hinder protein movements within the cell. Researchers from Heidelberg University and the German Cancer Research Center have succeeded in mapping the intracellular topology by observing proteins in living cells on multiple time and length scales. By ...

Rice University researchers optimize photoluminescent probes to study DNA and more

10-Sep-2012 - Sorting good data from bad is critical when analyzing microscopic structures like cells and their contents, according to researchers at Rice University. The trick is to find the right window of time through which to look.A new paper by the Rice lab of Angel Martí, an assistant professor of ...

Dot Products: Analytical Applications of Enzymatic Growth of Quantum Dots

18-Jun-2010 - The search for time and cost effective as well as sensitive methods for bioanalytical assays is currently of great interest. At the center of Biofunctional Nanomaterials in San Sebastian (Spain), Valery Pavlov and his co-workers are undertaking research in the area of the design and preparation ...