Visualising the Invisible: Active Sites in Antibacterial Nanomaterials

Fluorescence lifetime microscopy has great potential to systematically enhance the effectivenes of antibacterial nanomaterials

20-Dec-2024 - Interest in antibacterial nanomaterials has surged due to the growing threat of antibiotic-resistant microbes. A particularly promising strategy involves the use of nanomaterials that generate reactive oxygen species upon exposure to light, effectively combating microorganisms. However, a key ...

A stronghold in the fight against viruses - new bacterial immune system decoded

International research team describes for the first time the structure and function of the Zorya system

16-Dec-2024 - Bacteria are constantly infected by viruses, so-called phages, which use the bacteria as host cells. However, in the course of evolution, bacteria have developed various strategies to protect themselves from these attacks. Many of these bacterial immunity systems have been known for a long time. ...

Cost-effective modular system for optical imaging from the 3D printer

Like building with Lego bricks

14-Oct-2024 - Making modern microscopy and spectroscopy methods accessible to as many users as possible - Prof. Thorben Cordes and his doctoral student Gabriel G. Moya Muñoz have dedicated themselves to this goal. Cordes joined the Faculty of Chemistry and Chemical Biology (CCB) at TU Dortmund University as ...

What triggers the programmed cell death mechanism?

Development and combination of various microscopic and spectroscopic techniques

13-Sep-2024 - How can molecular structures be analysed when the resolution of the techniques available is not sufficient? Researchers from the fields of physics, chemistry and medicine at Heinrich Heine University Düsseldorf (HHU) have combined and further developed various microscopic and spectroscopic ...

Testing how well biomarkers work

Researchers have developed a method to determine how reliably target proteins can be labeled using super-resolution fluorescence microscopy

02-May-2024 - Modern microscopy techniques make it possible to examine the inner workings of cells in astonishing detail. “We can now observe the arrangement and interaction of individual proteins under the microscope,” says Professor Ralf Jungmann, Chair of Molecular Physics of Life at LMU and Max Planck ...

Hepatitis C Virus Infection: Discovery of Unexpected Proviral Effect of Guanylate-Binding Protein 1 (GBP1)

02-Apr-2024 - A research team from the Paul-Ehrlich-Institut has gained important insights into the role of the human guanylate-binding protein 1 (GBP1) in hepatitis C virus infection. Their results show that GBP1 performs a previously unknown function, that of a proviral factor, during the HCV life cycle. ...

Microscopy: Overcoming the traditional resolution limit for the fast co-tracking of molecules

Researchers have developed an innovative method to simultaneously track rapid dynamic processes of multiple molecules at the molecular scale

16-Feb-2024 - Processes within our bodies are characterized by the interplay of various biomolecules such as proteins and DNA. These processes occur on a scale often within a range of just a few nanometers. Consequently, they cannot be observed with fluorescence microscopy, which has a resolution limit of ...

Tracking Molecules at Turbo Speed

Researchers devise method to speed up observations of high-throughput microbiological process

17-Jan-2024 - Being able to observe micro-organisms and their cellular components is key to understanding fundamental processes that go on inside cells—and thus potentially developing new medical treatments. Microbiologists and biophysicists from the University of Bonn have now developed a method that makes ...

Enabling early detection of cancer: AI helps

Blood cells reveal tumours in the body: Researchers achieve an advance with the development of a test for early diagnosis of cancer

18-Dec-2023 - The ability to detect a developing tumour at a very early stage and to closely monitor the success or failure of cancer therapy is crucial for a patient’s survival. A breakthrough on both counts has now been achieved by researchers at the Paul Scherrer Institute PSI. Researchers led by G.V. ...

AI-driven breakthroughs in cells study: advancements in super-resolution microscopy

By integrating AI with super-resolution microscopy, cellular biology is advancing in new and exciting ways

12-Dec-2023 - In 2014, the Nobel Prize in Chemistry celebrated the breakthroughs in super-resolution microscopy, a technology that allows us to capture highly detailed images of small parts of cells using fluorescent microscopy. Despite its success, the resolution of super-resolution microscopy still can’t ...