Demystifying the 'Parkinson Protein'

Research team succeeds in directly observing the membrane binding of α-synuclein in living cells

11-Mar-2021 - The protein α-synuclein is one of the most abundant proteins in the human brain. It is often referred to as the "Parkinson protein", as deposition of this protein in brain cells is a hallmark of Parkinson's disease. Despite the high interest of biomedical research in the protein, many questions ...

Observing proteins in their natural environment

11-Feb-2020 - Proteins can be responsible for the fact that the active ingredients of drugs are simply released from the target cells. You can watch them do this now. Certain medications, such as those used to treat cancer, lose their effect because proteins in the membrane of the target cell simply expel them ...

New technique for in-cell distance determination

21-Mar-2019 - Researchers from the University of Konstanz, Bielefeld University and ETH Zurich demonstrate for the first time that the pulsed EPR technique RIDME (relaxation-induced dipolar modulation enhancement) can be used for in-cell distance determination in biomacromolecules. Applied within the cell, ...