Drug design - 10 News from the science department by Max-Planck-Gesellschaft

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Drug design - 10 News from the science department by Max-Planck-Gesellschaft

Tip: You can further refine your news selection by industries.

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Electrochemistry Paves the Way: Sustainable Synthesis Method Reveals N-Hydroxy Modifications for Pharmaceuticals

Closing knowledge gaps - new findings on heterocycles

18-Apr-2024 - New highly selective and scalable electro-organic synthesis of novel benzo[e]-1,2,4-thiadiazine-1,1-dioxides which represent an important structural motif of APIs (active pharmaceutical ingredients) modified with a unique N-hydroxy moiety. Recently published research results enable preparative ...

drug design electrochemistry heterocycles
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From thousands of hours to a few minutes: Software Speeds Up Drug Development

Researchers develop novel method to predict the morphology of sugar coats on clinically relevant proteins within minutes

05-Mar-2024 - Sugars cover nearly all proteins present at the surface of the cells in our bodies, forming a shield around the proteins. Thus, these sugars influence how cells interact with their environment including pathogens, playing an important role in medical drug development. GlycoSHIELD, a new ...

drug design glycans proteins
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Homogeneous hydrogenolysis reaction with molecular palladium catalyst

New method enables simple tritium labeling and could provide added value to the discovery and development of pharmaceuticals

20-Dec-2021 - Tritium 3H, a radioactive isotope of hydrogen, is commonly used in medicinal chemistry as a label to follow the course of a drug in the human body. Chemists like to use the technique to evaluate drug candidates and their metabolism. However, synthesis of the radiolabeled molecules is ...

drug design palladium catalysts tritium
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Characterized drugs show unexpected effects

Known and yet unexpected: many active substances influence the cholesterol homeostasis and thereby possibly a SARS-CoV-2 infection

26-Jul-2021 - Every innovative drug starts with the search for an active substance targeting key players in disease-related processes. However, there is no perfect drug that affects the one target in the body: no effect without side effects, as also described in most medicine information leaflets. A group of ...

drug design active ingredient candidates active ingredient search
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Efficiently smuggling drugs into cells

New method makes it easier than before to test new therapies

17-May-2021 - A new, patented method called Progressive Mechanoporation makes it possible to mechanically disrupt the membranes of cells for a short time period and let drugs or genes inside cells. In this way, researchers can test new therapies more easily than before. Modern vaccines such as those against ...

drug design biochips drug developments
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Stimulating the Immune System to Fight Cancer

Scientists find immunoregulatory substances with newly developed test system

26-Mar-2021 - Cancer cells have evolved mechanisms to escape the body's immune defense. Agents that prevent immune escape are attractive targets for the development of new cancer therapies. A group of scientists led by Herbert Waldmann and Slava Ziegler at the Max Planck Institute of Molecular Physiology in ...

drug design active ingredient research cancer
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Midbrain organoids for automated chemical screening and disease research

Max Planck Innovation licenses process for the generation of organ-like tissue aggregates to biotech company StemoniX

05-Nov-2020 - Sometimes hundreds of thousands of potential therapeutics need to be tested in large-scale, fully automated experiments to identify a single effective drug. Most compounds do not work as desired, and some are even toxic. Since the development of the induced Pluripotent Stem (iPS) Cell technology ...

drug design active ingredient research high-throughput methods
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Inspiring new drug discovery by pseudo natural products

New class of natural substances "starves" cancer cells

02-Nov-2018 - Almost a third of the available pharmaceuticals is based on natural products. The discovery of new natural products-inspired drugs however, is slow due to their limited chemical diversity, their high chemical complexity and the resulting low yields. The group of Herbert Waldmann has found a way ...

drug design cancer cells natural products

Max Planck Society grants technology for cancer therapy

Daiichi Sankyo, Max Planck Innovation and Lead Discovery Center announce cancer research collaboration

18-Jul-2017 - Daiichi Sankyo, Max Planck Innovation, and the Lead Discovery Center have signed an agreement providing Daiichi Sankyo with the option to receive the exclusive rights to a new lead compound for the treatment of cancer to be discovered and developed at the Lead Discovery Center. This new ...

drug design cancer cancer cells

A fingerprint for genes

Max Planck scientists develop new strategy to play major role in research on human diseases

09-Mar-2010 - Cells may not have a mouth, but they still need to ingest substances from the external environment. If this process - known as endocytosis - is affected, it can lead to infectious diseases or cardio-vascular diseases, cancer, Huntington’s and diabetes. In cooperation with the Center for ...

drug design bacteria biology

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