New Partnership of CELLphenomics and Kyan Therapeutics

This partnership aims to offer an efficient approach to expedite drug development process in the biopharmaceutical industry

20-Apr-2023 - CELLphenomics and KYAN Therapeutics announced their new partnership. By combining KYAN's technology platform, Optim.AI™ - which utilizes artificial intelligence to predict the effects of drug combinations and CELLphenomics' proprietary PD3D® technology, this partnership aims to offer an efficient ...

Bungled cell division drives cancer cells of childhood tumors to death

Cancer researchers have discovered a mechanism that can activate the self-destruction of cancer cells of childhood tumors

22-Sep-2021 - A drug combination already being tested in other cancers caused the cancer cells to accumulate errors in their genetic material in mice, causing the bone and soft tissue tumors to shrink in the laboratory. The scientists from the Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg ...

Antibiotic interaction testing made easy

New high-speed test shows how antibiotics combine to kill bacteria

21-Sep-2020 - Researchers at Uppsala University have developed a new method to determine - rapidly, easily and cheaply - how effective two antibiotics combined can be in stopping bacterial growth. The new method is simple for laboratories to use and can provide greater scope for customising treatment of ...

How antibiotics interact

Understanding bottleneck effects in the translation of bacterial proteins can lead to a more effective combination of antibiotics

25-Aug-2020 - It is usually difficult to predict how well drugs will work when they are combined. Sometimes, two antibiotics increase their effect and inhibit the growth of bacteria more efficiently than expected. In other cases, the combined effect is weaker. Since there are many different ways of combining ...

Antibiotic tolerance reduces the ability to prevent resistance under drug combination therapies

10-Jan-2020 - Antimicrobial tolerance can promote the evolution of antimicrobial resistance even under combination drug treatments widely used and expected to prevent it from occurring, a new study finds. The results suggest the need to consider drug tolerance when designing antibiotic treatments to prevent ...

Fruit flies live longer with combination drug treatment

Combination drug treatment may one day be helpful at preventing age-related diseases in people

02-Oct-2019 - A triple drug combination has been used to extend the lifespan of fruit flies by 48% in a new study led by UCL and the Max Planck Institute for Biology of Ageing. The three drugs are all already in use as medical treatments: lithium as a mood stabiliser, trametinib as a cancer treatment and ...

Cocktail of common antibiotics can fight resistant E. coli

Combination treatment could become an effective measure against antibiotic resistance

22-Feb-2019 - A group of scientists in Denmark is trying to get one step ahead in the battle against antibiotic resistance. Today, many disease-causing bacteria acquire resistance genes, which make antibiotic treatment ineffective. Especially, one gene, CTX-M-15, encoding an extended spectrum beta-lactamase ...

Artificial intelligence helps Stanford researchers predict drug combinations' side effects

11-Jul-2018 - Last month alone, 23 percent of Americans took two or more prescription drugs, according to one CDC estimate, and 39 percent over age 65 take five or more, a number that's increased three-fold in the last several decades. And if that isn't surprising enough, try this one: in many cases, doctors ...

Combining antibiotics changes their effectiveness

06-Jul-2018 - The effectiveness of antibiotics can be altered by combining them with each other, non-antibiotic drugs or even with food additives. Depending on the bacterial species, some combinations stop antibiotics from working to their full potential whilst others begin to defeat antibiotic resistance, ...

Targeting the engine room of the cancer cell

20-Jun-2018 - Researchers at Columbia University Irving Medical Center (CUIMC) have developed a highly innovative computational framework that can support personalized cancer treatment by matching individual tumors with the drugs or drug combinations that are most likely to kill them. The study by Dr. Andrea ...