New fuel-delivery route for cells identified

Findings shed light on chronic diseases, aging

10-Jan-2019 - Scientists at Washington University School of Medicine in St. Louis have identified a previously unknown route for cellular fuel delivery, a finding that could shed light on the process of aging and the chronic diseases that often accompany it. With age, cells gradually lose their ability to take ...

Making an eye for you

The underlying mechanisms of 3D tissue formation

27-Nov-2018 - If you want to build an organ, such as for transplant, you need to think in 3D. Using stem cells, scientists for some time have been able to grow parts of organs in the lab, but that is a far cry from constructing an actual, fully-formed, functioning, three-dimensional organ. For students of ...

Principles of limb regeneration in salamanders show link to mammals

01-Oct-2018 - Scientists have long argued over which cells enable salamanders to grow back lost limbs. By tracking lineages and characterising individual cells, researchers could now show that connective tissue cells develop stem-cell-like properties and underlie the regeneration of legs. Among all four-legged ...

Creating a family tree for each body cell in real time

Evolving genetic barcodes show origin of cells in vivo

13-Aug-2018 - All humans begin life as a single cell that divides repeatedly to form two, then four, then eight cells, all the way up to the ~26 billion cells that make up a newborn. Tracing how and when those 26 billion cells arise from one zygote is the grand challenge of developmental biology, a field that ...

Genetic screening before embryo transfer fails to improve the chance of a baby

06-Aug-2018 - The genetic screening of fertilised eggs for embryo selection in assisted reproduction makes no difference to live birth rates, according to results from the largest published study of its kind. Results from this multicentre randomised controlled trial, say the authors, confirm the "widely ...

Seeing how cells work as never before

17-Jul-2018 - Yale is adding microscopy that provides an unprecedented view of specimens whose thickness had thwarted close inspection Biological structures exist and function in three dimensions, but the limitations of imaging technology have long meant that scientists could examine only two dimensions in ...

Tracking protein’s role in stem cell function

26-Mar-2018 - MCL-1 is a member of the BCL-2 family of proteins important for blocking apoptosis, or programmed cell death. Many types of cancer cells escape the body’s effort to kill them by overexpressing MCL-1. However, new evidence from Vanderbilt University researchers indicates that MCL-1 also helps ...

Active genetics technology opens new horizons

08-Feb-2018 - In 2015, University of California San Diego biologists Ethan Bier and Valentino Gantz developed a breakthrough technology known as "active genetics," which results in parents transmitting a genetic trait to most of their offspring (instead of 50 percent receiving the trait under standard ...

Super-silenced DNA hints at new ways to reprogram cells

09-Jan-2018 - Newly described stretches of super-silenced DNA reveal a fresh approach to reprogram cell identity to use in regenerative medicine studies and one day in the clinic, according to a study by investigators from the Perelman School of Medicine at the University of Pennsylvania. "In the past, most ...

Cellular clean-up can also sweep away forms of cancer

13-Nov-2017 - Two new research papers reinforce the benefits of a novel therapy that hijacks the cell’s own protein degradation machinery to destroy cancer cells, Yale researchers report Nov. 9 in the journal Cell Chemical Biology. The new approach to drug discovery, called Proteolysis Targeting Chimeras or ...