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Using CRISPR to decipher whether gene variants lead to cancer

There are thousands of mutations in the human genome that are suspected of playing a role in cancer, but whose exact function has never been clarified

14-Nov-2024 - Researchers at ETH Zurich have combined two gene editing methods. This enables them to quickly investigate the significance of many genetic mutations involved in the development and treatment of cancer. In recent years, scientists have created a range of new methods based on CRISPR-Cas technology ...

CRISPR cancer gene variants

Diabetes switch in DNA

Promising approach for personalised diabetes therapy

07-Nov-2024 - They are underestimated genetic control elements: it is known that changes in the genome can trigger diabetes. But now researchers at the University Hospital Ulm and the INSERM Cochin Institute in Paris have shown that a previously under-researched region of the genome also plays a crucial role ...

CRISPR diabetes gene scissors

Use of “Genetic Scissors” Carries Risks

The study provides valuable insights for the development of gene-editing therapies

07-Nov-2024 - The CRISPR molecular scissors have the potential to revolutionize the treatment of genetic diseases. This is because they can be used to correct specific defective sections of the genome. Unfortunately, however, there is a catch: under certain conditions, the repair can lead to new genetic ...

CRISPR gene editing gene scissors

Are trees the future for the production of industrial chemicals?

Finding could help turn trees into affordable, greener industrial chemicals

22-Oct-2024 - Trees are the most abundant natural resource living on Earth’s land masses, and North Carolina State University scientists and engineers are making headway in finding ways to use them as sustainable, environmentally benign alternatives to producing industrial chemicals from petroleum. Lignin, a ...

CRISPR bacteria chemicals

Compact “gene scissor” enables effective genome editing

Much smaller genome editing tool

25-Sep-2024 - CRISPR-Cas is used broadly in research and medicine to edit, insert, delete or regulate genes in organisms. TnpB is an ancestor of this well-known “gene scissor” but is much smaller and thus easier to transport into cells. Using protein engineering and AI algorithms, UZH researchers have now ...

CRISPR gene editing gene scissors

PFAS influence the development and function of the brain

Study uncovers mechanism of action with new test method

06-Sep-2024 - Some per- and polyfluoroalkyl substances (PFAS) are poorly degradable and are also known as "forever chemicals". They adversely affect health and can lead to liver damage, obesity, hormonal disorders, and cancer. A research team from the Helmholtz Centre for Environmental Research (UFZ) has ...

CRISPR brain brain development

Precise Genetics: New CRISPR method enables efficient DNA modification

Two methods combined

01-Aug-2024 - The research group led by Prof. Markus Affolter at the Biozentrum, University of Basel, has developed a new method that further improves the existing CRISPR/Cas technologies: it allows a more precise and seamless introduction of tags into proteins at the gene level. This technology could ...

CRISPR CRISPR/Cas9 genetic markers

Sharpening the gene scissors together

Max Delbrück Centre and biotech start-up AlgenScribe cooperate

29-Jul-2024 - The Max Delbrück Center, Berlin, and the biotech company AlgenScribe from Nice have agreed to cooperate to further develop their gene-editing tools. The aim is to utilize synergies, accelerate research, and ultimately develop cell therapies for genetically determined diseases. A special kind of ...

CRISPR cell therapies CRISPR/Cas9

A new addition to the CRISPR toolbox: Teaching the gene scissors to detect RNA

Researchers present the PUMA technology for the precise detection of RNA with DNA-cutting Cas12 nucleases

18-Jul-2024 - CRISPR-Cas systems, defense systems in bacteria, have become a plentiful source of technologies for molecular diagnostics. Researchers at the Helmholtz Institute for RNA-based Infection Research (HIRI) in Würzburg have expanded this extensive toolbox. Their novel method, called PUMA, enables the ...

CRISPR biomarkers diagnostics

Eppendorf Award for Young European Investigators 2024 goes to Clemens Plaschka, Austria

In addition to the winner of the Eppendorf Award 2024, two finalists were honored: Irma Querques and Phong Nguyen

03-Jul-2024 - This year, the Hamburg based life sicences company Eppendorf SE is awarding its research prize for the 29th time. The independent jury chaired by Prof. Laura Machesky, Cambridge, UK, selected Dr. Clemens Plaschka, IMP - Institute of Molecular Pathology, Vienna, Austria as the winner of the ...

CRISPR Eppendorf Award for Young European Investigators messenger RNA