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How the body’s natural killer cells could fight leukemia

Research into new therapies

20-Dec-2024 - Every year, some 13,000 people in Germany are diagnosed with leukemia. Despite intensive chemotherapy, around one in two of them die. Making matters worse is the fact that the therapies currently available have severe side effects and inhibit the formation of new healthy blood cells in ...

CRISPR acute myeloid leukemia antigen receptors

Activating the hidden pharmaceutical potential of bacteria

Researchers develop a new genetic method for the production of new active ingredients in bacteria

17-Dec-2024 - Microorganisms produce a wide variety of natural products that can be used as active ingredients to treat diseases such as infections or cancer. The blueprints for these molecules can be found in the microbes' genes, but often remain inactive under laboratory conditions. A team of researchers at ...

CRISPR active ingredient production active ingredient research

CRISPR-Cas technology: ETH researchers have uncovered a serious side effect

A molecule designed to make the process more efficient destroys parts of the genome

05-Dec-2024 - Genome editing with various CRISPR-Cas molecule complexes has progressed rapidly in recent years. Hundreds of labs around the world are now working to put these tools to clinical use and are continuously advancing them. CRISPR-Cas tools allow researchers to modify individual building blocks of ...

CRISPR cancer gene editing

Using CRISPR to decipher whether gene variants lead to cancer

There are thousands of mutations in the human genome that are suspected of playing a role in cancer, but whose exact function has never been clarified

14-Nov-2024 - Researchers at ETH Zurich have combined two gene editing methods. This enables them to quickly investigate the significance of many genetic mutations involved in the development and treatment of cancer. In recent years, scientists have created a range of new methods based on CRISPR-Cas technology ...

CRISPR cancer gene variants

Diabetes switch in DNA

Promising approach for personalised diabetes therapy

07-Nov-2024 - They are underestimated genetic control elements: it is known that changes in the genome can trigger diabetes. But now researchers at the University Hospital Ulm and the INSERM Cochin Institute in Paris have shown that a previously under-researched region of the genome also plays a crucial role ...

CRISPR diabetes gene scissors

Use of “Genetic Scissors” Carries Risks

The study provides valuable insights for the development of gene-editing therapies

07-Nov-2024 - The CRISPR molecular scissors have the potential to revolutionize the treatment of genetic diseases. This is because they can be used to correct specific defective sections of the genome. Unfortunately, however, there is a catch: under certain conditions, the repair can lead to new genetic ...

CRISPR gene editing gene scissors

Are trees the future for the production of industrial chemicals?

Finding could help turn trees into affordable, greener industrial chemicals

22-Oct-2024 - Trees are the most abundant natural resource living on Earth’s land masses, and North Carolina State University scientists and engineers are making headway in finding ways to use them as sustainable, environmentally benign alternatives to producing industrial chemicals from petroleum. Lignin, a ...

CRISPR bacteria chemicals

Compact “gene scissor” enables effective genome editing

Much smaller genome editing tool

25-Sep-2024 - CRISPR-Cas is used broadly in research and medicine to edit, insert, delete or regulate genes in organisms. TnpB is an ancestor of this well-known “gene scissor” but is much smaller and thus easier to transport into cells. Using protein engineering and AI algorithms, UZH researchers have now ...

CRISPR gene editing gene scissors

PFAS influence the development and function of the brain

Study uncovers mechanism of action with new test method

06-Sep-2024 - Some per- and polyfluoroalkyl substances (PFAS) are poorly degradable and are also known as "forever chemicals". They adversely affect health and can lead to liver damage, obesity, hormonal disorders, and cancer. A research team from the Helmholtz Centre for Environmental Research (UFZ) has ...

CRISPR brain brain development

Precise Genetics: New CRISPR method enables efficient DNA modification

Two methods combined

01-Aug-2024 - The research group led by Prof. Markus Affolter at the Biozentrum, University of Basel, has developed a new method that further improves the existing CRISPR/Cas technologies: it allows a more precise and seamless introduction of tags into proteins at the gene level. This technology could ...

CRISPR CRISPR/Cas9 genetic markers