An international study proposes stool analysis for early detection of pancreatic cancer

A genetic signature of 27 microorganisms in stool defines the high-risk population for pancreatic ductal adenocarcinoma

10-Mar-2022 - Pancreatic cancer is not one of the most frequently diagnosed cancers, but it is one of the most lethal due to its early local extension and metastatic behaviour. Some of the reasons for this high fatality rate are late diagnosis of the disease, especially since symptoms are unspecific and appear ...

An international study co-led by CNIO identifies a 'sensor' that activates cell migration

13-Mar-2019 - The cytoskeleton is a structure that not only helps cells maintain their shape and internal organisation, but also enables them to perform functions like movement and migration, that is to say, the movement that takes cells far from the place where they are initially located. Migration forms an ...

New cancer treatments linked to cardiovascular alterations

11-Jul-2017 - Plk1 inhibitors have recently been acknowledged as an "Innovative Therapy for leukaemia" by the US Food and Drug Administration (FDA). However, a study by researchers from the Spanish National Cancer Research Centre (CNIO) suggests that prolonged use of these inhibitors can not only lead to ...

State-of-the-art text mining technologies for chemistry

23-Jun-2017 - The Biological Text Mining Unit at the Spanish National Cancer Research Centre (CNIO) together with with researchers at the Center for Applied Medical Research (CIMA), of the University of Navarra, in Pamplona, and the Barcelona Supercomputing Centre (BSC-CNS) have published the first exhaustive ...

New combined therapy to treat cancer

10-Feb-2014 - A large part of the effort dedicated to cancer research is directed towards the search for combinations of existing drugs—many of which have already been introduced into clinical practice—that permit higher overall survival rates and improvements in the quality of life of cancer patients. Marcos ...

'Molecular scaffolding' that maintains skin structure and organisation

The connection between 2 different cell components -- microtubules and cell-cell junctions -- holds skin stem cells together to support skin architecture

20-Jan-2014 - The human body is daily exposed to external assaults such as bacteria, ultraviolet light or chemical agents. Skin, the largest organ of the body, is the first line of defense against these agents. Skin performs this function thanks to the close connections established between its cells (e.g. ...

Merck Enters into License Agreement with the Spanish National Cancer Research Centre (CNIO)

New agreement aims to translate CNIO research into new potential treatment options for cancer patients

20-Dec-2013 - Merck Serono, the biopharmaceutical division of Merck, announced that a license agreement has been signed with the Spanish National Cancer Research Centre (CNIO) in Madrid in the area of cancer drug development. The global agreement will build upon CNIO research discoveries to encourage the ...

Spanish scientists identify a new ancestral enzyme that facilitates DNA repair

PrimPol allows cells to make copies of their DNA even when it is damaged, and prevents breaks in the chromosomes

22-Nov-2013 - Every day, the human body produces new cells to regenerate tissues and repair those that have suffered injury. Each time this happens, the cells make copies of their DNA that they will pass on to the resulting daughter cells. This process of copying the DNA, also called replication, is very ...

Delve into the behavior of cohesins

22-Oct-2013 - Cohesins are protein complexes that join the two copies of each chromosome—called sister chromatids—to ensure that they are shared fairly between the daughter cells during cell division. In this way, each daughter cell receives exactly the same genetic information from the parent cell. Pds5 is a ...

Spanish researchers sequence non-infiltrating bladder cancer exome

21-Oct-2013 - Spanish researchers sequence non-infiltrating bladder cancer exome The study's authors identify new genetic pathways and new genes involved in bladder cancer; The genetic signature of these patients is a first step towards understanding the biology of this illness and improving patient ...