Cells - 14 News from the science department by Uni Köln

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Cells - 14 News from the science department by Uni Köln

Tip: You can further refine your news selection by industries.

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How gene regulation changes over a lifetime

Scientists have discovered that coordination between basic cellular processes is lost with increasing age

05-Sep-2024 - Gene regulation in our cells – the decision when which proteins are produced for the various processes of the cell – is strictly regulated. It has long been assumed that this regulation deteriorates with age. But until now, it has been unclear how exactly the regulation of individual processes ...

cells cellular processes gene regulation
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New compound from blessed thistle promotes functional nerve regeneration

Researchers have found a new use for Cnicin

24-Apr-2024 - Blessed thistle (Cnicus benedictus) is a plant in the family Asteraceae and also grows in our climate. For centuries, it has been used as a medicinal herb as an extract or tea, e.g. to aid the digestive system. Researchers at the Center for Pharmacology of University Hospital Cologne and at the ...

cells nerve cells axons
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New antibodies neutralize resistant bacteria

Broadly neutralizing antibodies are already being used to fight viruses: This approach could also help to treat infections with multi-resistant bacteria in the future

07-Nov-2023 - A research team has discovered antibodies that could lead to a new approach to treating acute and chronic infections with the bacterium Pseudomonas aeruginosa. Due to its numerous resistance mechanisms, P. aeruginosa is associated with high morbidity and mortality and can cause complicated ...

cells immune cells antibiotic resistance
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How cells age: genes are read faster but less accurately with age

Slowing down RNA polymerase II extends lifespan and improves health

25-Jul-2023 - The genome of all living organisms contains information for the production of cell components, i.e. the proteins, which are necessary for the maintenance of cell function. An important step in the process of protein production is the reading and copying of this information from the genes, ...

cells ageing cellular aging
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How a metabolite causes inflammation and disease

The accumulation of the metabolite fumarate in the mitochondrion, the powerhouse of a cell, can cause inflammation associated with diseases such as cancer and autoimmune diseases

13-Mar-2023 - A new study shows for the first time a connection between a mitochondrial metabolite and the activation of an inflammatory response. Mitochondria are functional units of our cells that fulfil important tasks, i.e. chemical reactions, for the functioning of the cell. One of these tasks is the ...

cells autoimmune diseases inflammation
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Powerhouses of the Cells: Mitochondria Have a Waste Disposal Mechanism to Get Rid of Mutated mtDNA

A research team has identified a molecular target that could open up new therapeutic options to treat aging-associated diseases

17-Nov-2022 - Scientists at the University of Cologne have discovered how cells can eliminate mutated mitochondrial DNA (mtDNA). Mitochondria are the powerhouses of our cells. Due to their evolutionary descent from bacteria, they still have genetic material packaged in chromosome-like structures (nucleoids). ...

cells age-related diseases ageing
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One Zip of Alcohol is Enough to Modify the Brain

Even a single dose of drinking alcohol – ethanol – can permanently alter synapses and mitochondrial movement in the brain’s neurons

29-Aug-2022 - That has consequences for the brain’s reward learning and can potentially lead to later alcohol addiction. A research team from the University of Cologne and the Universities of Mannheim and Heidelberg has found that even the single administration of alcohol permanently alters the morphology of ...

cells nerve cells alcohol
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No more binge eating: signal pathway in the brain that controls food intake discovered

Specific inhibitors of lipid synthesis could serve as new obesity therapies

29-Jun-2022 - A group of researchers has developed an entirely novel approach to treating eating disorders. The scientists showed that a group of nerve cells in the hypothalamus (so-called AgRP, agouti-related peptide neurons) control the release of endogenous lysophospholipids, which in turn control the ...

cells nerve cells adipositas
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Stiffness of skin tissue determines renewal capacity

New insights into the causes of aging

12-Jul-2021 - An international team of researchers from the Universities of Cologne and Helsinki have discovered that the ability of stem cells to proliferate and renew organs is regulated by the stiffness of the surrounding tissue. This finding may have implications for improving the regeneration of aged ...

cells stem cells chromatin
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Fine-tuning stem cell metabolism prevents hair loss

Research team has shown in mice that Rictor, a protein that helps to regulate the growth, energy, and oxygen consumption of cells, plays a key role in the cellular metabolism and longevity of hair follicle stem cells

02-Oct-2020 - A team of researchers from Cologne and Helsinki has discovered a mechanism that prevents hair loss: hair follicle stem cells, essential for hair to regrow, can prolong their life by switching their metabolic state in response to low oxygen concentration in the tissue. The team was led by ...

cells stem cells cell metabolism
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