Programmable DNA hydrogels for advanced cell culture and personalized medicine

21-Aug-2023 - The team of Dr. Elisha Krieg at the Leibniz Institute of Polymer Research Dresden has developed a dynamic DNA-crosslinked matrix (DyNAtrix) by combining classical synthetic polymers with programmable DNA crosslinkers. DNA’s highly specific and predictable binding gives researchers unparalleled ...

Successfully reducing animal testing: The 3Rs principle in fish research

Investigation of cell cultures provides insights into climate change

23-Jun-2023 - According to animal experimentation statistics, fish are the second most commonly used group of animals in research after mice. They play an important role in aquaculture and also serve as model animals in various research areas. "Applying the 3Rs principle means reducing, refining and replacing ...

First synthetic tissue model developed in which blood vessels can grow

02-Aug-2021 - A research team headed by biomedical engineer Dr Britta Trappmann from the Max Planck Institute for Molecular Biomedicine in Münster, Germany, has developed a cell culture system in which, for the first time, a functional blood vessel system is able to grow within a framework made of synthetic ...

Embryonic development in cell culture

Research group can for the first time reproduce early human heart development in a culture dish using human pluripotent stem cells

11-Feb-2021 - To study early stages in embryonic development in the cell culture dish, scientists use so-called human pluripotent stem cells (hPSC). These are cells with have remarkablespecial properties that can be multipliedas they can indefinitely multiply and are capable of forming any functional cell type ...

Do chemicals make you fat?

The EU research project EDCMET is investigating the effect of endocrine disruptors on metabolism

28-Jan-2019 - January 2019 saw the launch of the EU research project EDCMET, in which scientists from the German Federal Institute for Risk Assessment (BfR) are also involved. EDCMET stands for "Metabolic effects of Endocrine Disrupting Chemicals: novel testing METhods and adverse outcome path-ways" and is ...

New model for vascular and tumour research

VOGIM cell culture technique allows tumour growth to be observed

22-Dec-2015 - Two characteristic features of malignant tumours are that they form massive blood vessels and bypass the immune system. A new cell culture technique allows the processes of tumour growth to be studied directly and in real time, without the need for complex experiments using live animals. The ...

Drug discovery for Parkinson’s disease: Researchers Grow Neurons in 3D

02-Jul-2015 - The progressive loss of neurons in the brain of Parkinson’s patients is slow yet inexorable. So far, there are no drugs that can halt this insidious process. Researchers at the Luxembourg Centre for Systems Biomedicine (LCSB) of the University of Luxembourg have now managed to grow the types of ...

Kallistem obtains complete human spermatozoa in vitro

07-May-2015 - Kallistem, which develops cell culture technologies in reproductive biology, announces a world first: human spermatogenesis in vitro. At the end of 2014 the company was able to produce fully formed human spermatozoa in the laboratory setting, using patient testicular biopsies containing only ...

New screening tool could speed development of ovarian cancer drugs

12-Feb-2015 - University of Chicago Medicine researchers have built a model system that uses multiple cell types from patients to rapidly test compounds that could block the early steps in ovarian cancer metastasis. Their three-dimensional cell-culture system, adapted for high-throughput screening, has enabled ...

Takeda Announces New Initiative in Cell Culture-Based Influenza Vaccines

01-Sep-2010 - Takeda Pharmaceutical Company Limited announced that it has received an official notice from the Pharmaceutical Development Support Center with regard to the granting of a government subsidy for which it had applied. Takeda was notified in writing on July 6 of this decision, and the company has ...