Micro- and nanoplastics in the body are passed on during cell division

That plastic may increase metastasis of tumors

08-Mar-2024 - The gastrointestinal tract is already known to researchers as a major storage site for micro- and nanoplastic particles (MNPs) in the human body. A research consortium consisting of the University of Vienna, the Medical University of Vienna and other partners under the leadership of CBmed GmbH in ...

Immune system meets cancer: Checkpoint identified to fight solid tumors

Checkpoint PHDGH in tumor-associated macrophages influences immune response and tumor growth

29-Feb-2024 - A study by a scientific team from the University of Vienna and the MedUni Vienna, recently published in the top-class journal Cellular & Molecular Immunology, has a promising result from tumor research: The enzyme phosphoglycerate dehydrogenase (PHDGH) acts as a metabolic checkpoint in the ...

New method enabling therapeutical targeting of lactate transporters

New method hat allowed the discovery of specific inhibitors of a lactate transporter that is associated with cancer

02-Aug-2023 - Scientists from the Giulio Superti-Furga Lab at CeMM, the Research Center for Molecular Medicine of the Austrian Academy of Sciences, have developed a new method that allowed the discovery of specific inhibitors of a lactate transporter that is associated with cancer and other diseases areas. The ...

Artificial intelligence could improve therapy for lymphoma

09-Mar-2023 - Hodgkin’s lymphoma, a type of lymph node cancer, requires chemotherapy and radiation therapy that can be very stressful for patients. A research group in Vienna is working on a method to predict the course of the disease with the help of artificial intelligence algorithms. This would facilitate a ...

How “good cholesterol” gets to do even more good work

13-Aug-2019 - In order for a tumour to grow, it needs cholesterol to build new cell walls. At the same time, the so-called “good” cholesterol or high-density lipoprotein (HDL) is regarded as a protective factor against cancer. Schrödinger fellow Raimund Bauer investigated the effect of HDL on tumours more ...

Protein hitch hiking into the cancer cell: the next generation of platinum drugs

The young spin-off "P4 Therapeutics" was awarded with the "Der Brutkasten Media Award"

02-Jul-2019 - An interdisciplinary team of the University of Vienna and the Medical University of Vienna has developed a new platinum compound with great potential as anticancer drug. Based on a new strategy, scientists around Christian Kowol from the Department of Inorganic Chemistry, University of Vienna and ...

From metabolite profiles to molecular biomarkers for colorectal cancer

16-Apr-2019 - The aim of a European project (TRANSCAN) is to identify metabolite signatures that are associated with all stages in the development of colorectal cancer. Metabolomic analysis was performed on more than 2,000 plasma samples from individuals with colorectal cancer, colorectal adenoma and a control ...

Malignant pleural mesothelioma: new mechanism of spread discovered

17-Dec-2018 - Malignant pleural mesothelioma is divided into three subtypes, one of which is particularly aggressive. Researchers from the Comprehensive Cancer Center (CCC) of MedUni Vienna and Vienna General Hospital have now managed to discover a mechanism that contributes to this aggressive behaviour: the ...

Proven biochemistry methods for new skin cancer therapy

31-Jul-2018 - Like all other cells in the body, skin cancer cells need a cholesterol metabolism. With the support of the Austrian Science Fund FWF, a Viennese research group discovered deviations and particularities of this process in malignant melanoma that could help improve prognosis and therapy. For many ...

Precisely off the mark: Possible Cause Discovered For Failure of Targeted Liver Cancer Therapies

25-Nov-2014 - The failure of experimental liver cancer therapies directed specifically against the EGFR protein is presumably the result of insufficiently specific patient selection. This is the conclusion that can be drawn from data that were obtained within the framework of a project carried out by an ...