Stressful childhood experiences accelerate brain aging

Early identification and prevention of dementia in later life

18-Feb-2025 - Stressful or traumatic experiences in childhood have been shown to negatively impact an individual’s health as an adult. Those affected face an increased risk of illness and often suffer from depression, anxiety disorders, and cardiovascular or metabolic diseases. Until now, little has been known ...

New imaging analysis method revolutionizes the diagnosis of head and neck tumors

01-Nov-2024 - Head and neck cancers are among the ten most common cancers worldwide. Head and neck tumors account for about 3-5% of all cancers, with squamous cell carcinomas being the predominant form. They occur in areas such as the oral cavity, pharynx and larynx. An international team of researchers led by ...

Data-efficient foundation model for biomarker detection

Artificial intelligence for clinical pathology: A new multi-task approach

04-Sep-2024 - The use of Artificial Intelligence (AI) systems shows promise in medicine, where they can be used to detect diseases earlier, improve treatments, and ease staff workloads. But their performance depends on how well the AI is trained. A new multi-task approach to training AI makes it possible to ...

A new addition to the CRISPR toolbox: Teaching the gene scissors to detect RNA

Researchers present the PUMA technology for the precise detection of RNA with DNA-cutting Cas12 nucleases

18-Jul-2024 - CRISPR-Cas systems, defense systems in bacteria, have become a plentiful source of technologies for molecular diagnostics. Researchers at the Helmholtz Institute for RNA-based Infection Research (HIRI) in Würzburg have expanded this extensive toolbox. Their novel method, called PUMA, enables the ...

Faster neuroborreliosis diagnosis using biomarkers

Clear threshold value of the cellular messenger substance CXCL13 allows diagnosis of neuroborreliosis to be improved

11-Jul-2024 - A newly defined threshold for the concentration of the cytokine CXCL13 may improve the diagnosis of neuroborreliosis. The clinical diagnosis of this disease, which is caused by infections from tick bites, is still difficult and often occurs long after infection. CXCL13 now makes it possible to ...

AI model finds the cancer clues at lightning speed

Say goodbye to hours, even days, of detective work

08-Jul-2024 - Researchers at the University of Gothenburg have developed an AI model that increases the potential for detecting cancer through sugar analyses. The AI model is faster and better at finding abnormalities than the current semi-manual method. Glycans, or structures of sugar molecules in our cells, ...

UMC Utrecht and VectorY Therapeutics collaborate in ALS Biomarker Study

Finding these biomarkers is expected to help diagnose ALS and monitor disease progression and improve the design of future clinical studie

18-Jun-2024 - UMC Utrecht has enrolled its first patient for a new study to identify biomarkers of Amyotrophic Lateral Sclerosis (ALS). The observational investigator-initiated study is led by Professor Dr. Leonard van den Berg and supported by VectorY Therapeutics. VectorY Therapeutics is developing ...

Live long, stay healthy: Study reveals important health markers

5 tips for healthy ageing

05-Jun-2024 - In a recent study, the Leibniz Institute for Prevention Research and Epidemiology - BIPS has made significant progress in identifying health markers that are crucial for a long and healthy life. Led by Prof. Dr. Krasimira Aleksandrova and in close collaboration with the German Institute of Human ...

New disease discovered: How the immune system destroys the cerebellum

Study identifies new autoantibodies in cerebrospinal fluid as a possible biomarker for rapidly progressing cerebellitis

03-Jun-2024 - Cerebellar ataxia is a neurological disorder of the cerebellum. This important area at the back of the brain acts as a conductor, so to speak, coordinating our movements and keeping us in balance. This ability is impaired in cerebellar ataxia. Affected people can have difficulties walking, ...

Testing how well biomarkers work

Researchers have developed a method to determine how reliably target proteins can be labeled using super-resolution fluorescence microscopy

02-May-2024 - Modern microscopy techniques make it possible to examine the inner workings of cells in astonishing detail. “We can now observe the arrangement and interaction of individual proteins under the microscope,” says Professor Ralf Jungmann, Chair of Molecular Physics of Life at LMU and Max Planck ...