Predicting the mode of action of new anti-cancer drugs with AI

Acceleration of the development of new cancer drugs

22-Nov-2024 - Plants, fungi and bacteria produce a variety of active substances that alter cell metabolism, sometimes to the point of cell death. This makes them promising candidates for new drugs against cancer and other diseases. Although a diverse range of bioactives exists, the further development of new ...

Diseases beware! Researchers make crucial breakthrough in cell research

This method could have the potential for the next stage of drug delivery

28-Oct-2024 - It is a breakthrough in cell research that's poised to open up new possibilities in the fight against diseases. In cooperation with researchers from the China University of Petroleum, the working group of Dr. Werner Nau, Professor of Chemistry at Constructor University, has demonstrated the ...

Scientists discover "pause button" in human development

Findings have possible implications for reproductive technologies

30-Sep-2024 - Researchers at the Max Planck Institute for Molecular Genetics in Berlin (MPIMG) and the Institute of Molecular Biotechnology (IMBA) of the Austrian Academy of Sciences in Vienna have discovered a potential "pause button" in the earliest stages of human development. Whether humans can control the ...

Scientists from 33 European countries join forces to generate reference genomes for the continent's rich biological diversity

19-Sep-2024 - The European Reference Genome Atlas (ERGA) pilot project reports its success in uniting scientists from across Europe to produce high-quality reference genomes for 98 species. This marks a significant milestone in the quest to create a high-quality reference genome database for all European ...

Harnessing Mutations: A Breakthrough in Fruit Fly Genetics

A game-changing technique, TF-High-Evolutionary (TF-HighEvo), allows large-scale assessment of de-novo mutations in multicellular organisms

16-Sep-2024 - Developed in collaboration with researchers from the European Molecular Biology Laboratory (EMBL) and the Friedrich Miescher Laboratory of the Max Planck Society and published in Molecular Biology and Evolution, this technique provides fresh insights into the evolutionary dynamics of gene ...

How to live 400 years

Genome of the longest-lived vertebrate decoded: It is huge and has special repair capabilities

12-Sep-2024 - The Greenland Shark (Somniosus microcephalus), an elusive dweller of the depths of the northern Atlantic and the Arctic Ocean, is the world’s longest-living vertebrate, with an estimated lifespan of about 400 years. An international team of scientists has mapped the Greenland Shark’s genome for ...

When is the best time of day for cancer treatment?

Researchers are developing new methods to use the internal clock inside tumor cells to optimize cancer therapies

28-Aug-2024 - How effective medications are depends on various factors, including the time of day when they are administered. Why? Because our bodies don’t always function exactly the same. Instead, they follow the cycle set by their internal clock, otherwise known as circadian rhythm. But since each person’s ...

Strength Training Activates Cellular Waste Disposal

Regulated degradation of damaged cell components prevents heart failure and nerve diseases

27-Aug-2024 - The elimination of damaged cell components is essential for the maintenance of the body’s tissues and organs. An international research team led by the University of Bonn has made significant findings on mechanisms for the clearing of cellular wastes, showing that strength training activates such ...

Microbiome of the nose: removing iron from multi-resistant germs

Whether dangerous staphylococci survive in the nose depends on what other bacteria are present - and how they obtain iron.

09-Aug-2024 - A research team led by Simon Heilbronner, Professor of Microbiology at the LMU Biocenter, has investigated how different bacteria that can colonize the nasal cavity deal with the iron deficiency there and interact with each other. The results of the study, which was recently published in the ISME ...

Cracking the code of life: New AI model deciphers the hidden language of DNA

07-Aug-2024 - Scientists at TU Dresden have trained a large language model with human DNA. Researchers can use it to try to decode the complex information hidden in our genome. The AI treats human DNA like language, learning its rules and relationships to derive functional information about the DNA sequences. ...