Towards a better understanding of the human immune defense against RNA viruses

New findings in the fight against pandemics

08-Oct-2024 - An international research team led by Prof. Dr. Janosch Hennig from the University of Bayreuth has discovered how the TRIM25 protein contributes to defense against RNA viruses whose genetic material is contained as ribonucleic acid (RNA). The results provide a better understanding of the ...

Antiviral nasal spray for common colds or more severe respiratory diseases

Start-up G.ST Antivirals reports start of Phase II trial and announces appointment of Ronald Bruce Turner as new Chief Medical Officer

16-Apr-2024 - G.ST Antivirals, aspin-off from the Medical University of Vienna applying innovative, host cell-based strategies to develop broad-spectrum antivirals against respiratory tract infections, announced the appointment of Ronald Bruce Turner, MD, as new Chief Medical Officer (CMO). An expert in the ...

The virus hackers: RNAi therapy for viral respiratory diseases

Inhalation as a silver bullet

05-Feb-2024 - A research team from the Fraunhofer Institute for Toxicology and Experimental Medicine ITEM and the Hannover Medical School (MHH) have made significant progress in developing a new antiviral therapy. The drug, which is inhaled, uses RNAi to target and deactivate parainfluenza viruses before they ...

Mutating Hepatitis Viruses Make Drug Treatment More Difficult

Study paves the way for the next generation of active substances

31-Jan-2024 - A combination therapy with multiple drugs is more effective than just one active compound. To begin with, at least. Hepatitis E affects over 20 million people worldwide. It clears up without any consequences in most cases, but it can pose a risk to pregnant women and immunocompromised patients. ...

Prepared for the next virus pandemic

13 institutions from 6 countries set up European research platform

11-Jan-2024 - In collaboration with 12 partners from 6 countries, Jena University Hospital is establishing the Antivirus Pandemic Preparedness EuropeAn pLatform (APPEAL), a European research initiative aimed at enhancing preparedness for future pandemics. This EU funded collaboration will establish a ...

Cancer drug works against viruses

01-Sep-2023 - TWINCORE researchers describe a mechanism that inhibits virus replication and protects cells from damage. Interestingly, a drug that has already been approved could prove useful in combating various viruses. AIDS, the flu, COVID-19 - time and again, viral infections overtake entire regions of ...

CSIC researchers identify a new class of antivirals against covid-19

New antivirals act by blocking virus entry into the host cell through interaction with the 'spike' protein

07-Aug-2023 - Researchers from the Consejo Superior de Investigaciones Científicas at the Instituto de Química Médica (IQM-CSIC), the Instituto de Biología Integrativa de Sistemas (I2SysBio-CSIC-UV) and the Instituto de Biomedicina de Valencia (IBV-CSIC), members of the Plataforma Temática Interdisciplinar ...

Occludin protein plays key role in spread of coronavirus throughout body’s cells

Finding gives insight into how the virus spreads throughout the human body, may help development of antiviral drugs

04-May-2023 - While the coronavirus continues to infect people around the world, researchers at the University of Missouri have identified a specific protein inside the human body that plays a critical role in how the virus spreads from cell to cell after infection — a discovery that will help better ...

Monkeypox viruses remain sensitive to the available drugs

“We were really concerned that the virus could have changed and become resistant to the available therapies”

10-Jan-2023 - The mpox virus is closely related to the smallpox virus (variola virus), which caused large, deadly outbreaks before it was eradicated by vaccination at the end of the 1970s. While the smallpox virus led to very severe disease progression with a death rate of about 30 percent, mpox is milder. ...

Shedding New Light on Viruses

Analysis of viruses with a combination of mass spectrometry and X-ray laser

19-Dec-2022 - Professor Dr. Charlotte Uetrecht from the University of Siegen is studying the structures of proteins and protein complexes in coronaviruses and noroviruses, and how they change over the viral lifecycle. She is developing a new method to obtain as much information as possible about states of ...