30 News by American Association of Cancer Research

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30 News by American Association of Cancer Research

Tip: You can further refine your news selection by topics, departments, countries and industries.

Fat cells may inactivate chemotherapeutic drug

09-Nov-2017 - Adipocytes, or fat cells, can absorb and metabolize the chemotherapeutic agent daunorubicin, reducing the effectiveness of the drug and potentially contributing to poorer treatment outcomes. "Anthracyclines such as daunorubicin are important chemotherapy agents used in a variety of cancers in ...

adipocytes anthracyclines cancer

Higher nicotine, carcinogen levels among smokeless tobacco users compared with cig users

19-Nov-2015 - U.S. adults who used only smokeless tobacco products had higher levels of biomarkers of exposure to nicotine and a cancer-causing toxicant -- the tobacco-specific nitrosamine NNK -- compared with those who used only cigarettes. Even though smokeless tobacco is used less than cigarettes, it ...

biomarkers cancer nicotine

First-in-class investigational therapeutic shows early promise for lymphoma patients

11-Nov-2015 - Results from a phase I clinical trial showed that the first-in-class, investigational, anticancer therapeutic pevonedistat was safe, tolerable, and had some anticancer activity in heavily pretreated patients with relapsed/refractory lymphoma. The study was published in Clinical Cancer ...

cancer lymphoma pevonedistat

Modified CAR T cells can preferentially target cancer cells and spare normal cells

02-Sep-2015 - Engineering chimeric antigen receptor (CAR) T cells to lower their affinity for the protein epithelial growth factor receptor (EGFR) made the cells preferentially recognize and eliminate tumor cells that have high amounts of EGFR while sparing normal cells that have lower amounts of the protein, ...

cancer cells receptors

Cisplatin-resistant cancer cells sensitive to experimental anticancer drugs, PARP inhibitors

04-Apr-2013 - Poly (ADP-ribose) polymerase inhibitors may be a novel treatment strategy for patients with cancer that has become resistant to the commonly used chemotherapy drug cisplatin, according to data from a preclinical study published in Cancer Research. "Cisplatin is one of the most widely used ...

cancer cell lines cells

Noninvasive measurement enables use of IFP as potential biomarker for tumor aggressiveness

02-Oct-2012 - Researchers validated a method of noninvasive imaging that provides valuable information about interstitial fluid pressure of solid tumors and may aid in the identification of aggressive tumors, according to the results of a study published in Cancer Research.Many malignant solid tumors generally ...

magnetic resonance imaging tumors

PARP inhibitors may have clinical utility in HER2-positive breast cancers

18-Sep-2012 - Poly (ADP-Ribose) polymerase (PARP) inhibitors, shown to have clinical activity when used alone in women with familial breast and ovarian cancers linked to BRCA mutations, may be a novel treatment strategy in women with HER2-positive breast cancers, according to the results of a study published ...

breast cancer cancer ovarian cancer

Mechanisms of acquired chemoresistance in ovarian cancer identified

16-Aug-2012 - The presence of multiple ovarian cancer genomes in an individual patient and the absence or downregulation of the gene LRP1B are associated with the development of chemoresistance in women with the high-grade serous cancer subtype of ovarian cancer whose disease recurs after primary treatment. ...

cancer chemoresistance genomes

Gene identified in increasing pancreatic cancer risk

04-Jan-2012 - Mutations in the ATM gene may increase the hereditary risk for pancreatic cancer, according to data published in Cancer Discovery, a journal of the American Association for Cancer Research."There was significant reason to believe this clustering was due to genetics, but we had not, to this point, ...

genes oncology pancreatic cancer

Blood test could predict metastasis risk in melanoma

18-Apr-2011 - Scientists at Yale University have identified a set of plasma biomarkers that could reasonably predict the risk of metastasis among patients with melanoma, according to findings published in Clinical Cancer Research, a journal of the American Association for Cancer Research."The rate at which ...

biomarkers melanoma
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