New model system for the development of potential active substances used in condensate modifying drugs

Model system can break down fibrils into their constituent single units or liquid droplets for the first time

18-Nov-2024 - The origin of many diseases such as Alzheimer's or Parkinson's can be found at the molecular level in our body, in other words, in proteins. In a healthy system, these proteins are responsible for numerous physiological functions. In order to carry out certain tasks, they may also assemble in ...

Berlin-Based Neurotech Startup Secures Investment for the Development of a Digital Drug to Treat Alzheimer’s Disease

Activating the Memory System of the Brain with Software to Treat Alzheimer’s Disease

04-Nov-2024 - Nuuron is developing a fully digital Alzheimer’s therapy based on a proprietary neuromodulation technology. Nuuron’s algorithms produce ultra-high frequency, digital-photonic stimuli that activate the Memory System of Alzheimer’s patients, aiming to improve memory formation and memory recall. ...

Smartphone-assisted “scavenger hunt” identifies people at risk for dementia

Perspectives for early detection

11-Oct-2024 - Researchers from DZNE and Otto von Guericke University Magdeburg have identified individuals with increased risk for dementia using mobility data, recorded during a smartphone-based wayfinding task on the university campus. The findings, reported in the journal “PLOS Digital Health”, show the ...

Blood Testing for so-called MicroRNAs Can Detect Dementia

German-American research team highlights new diagnostic option for Alzheimer’s

23-Sep-2024 - Dementia due to Alzheimer’s disease and its preliminary stage can be detected by measuring so-called microRNAs in blood. Researchers from DZNE in Göttingen, together with US experts from Boston University and the Indiana University School of Medicine, report on this in the scientific journal ...

Evolutionarily Youngest Brain Regions Age First

"Our findings could contribute to the development of new treatment and prevention approaches for neurodegenerative diseases such as Alzheimer's"

20-Sep-2024 - A research team from Forschungszentrum Jülich and Heinrich Heine University Düsseldorf has discovered that the regions of the human brain that have expanded most recently in the course of evolution show the strongest aging effects. This is evident from comparisons with brain ageing in our closest ...

The ageing brain: Changes in gene activity detected in different cell types

Findings could provide starting points for slowing down the ageing process and delaying neurodegenerative diseases

10-Sep-2024 - Ageing is a complex biological process that also takes place in the brain. Researchers have discovered that the gene activity changes in different cell types in the brain. A certain type of neuron is particularly affected. In the long term, the findings could provide starting points for slowing ...

Cancer drug could treat early-stage Alzheimer’s disease, study shows

26-Aug-2024 - A type of drug developed for treating cancer holds promise as a new treatment for neurodegenerative diseases such as Alzheimer’s, according to a recent study by researchers at Penn State, Stanford University and an international team of collaborators. The researchers discovered that by blocking a ...

Do people with high blood pressure have a higher risk of Alzheimer’s disease?

20-Aug-2024 - People 60 and older with untreated high blood pressure may have an increased risk of Alzheimer’s disease compared to both people who have been or are being treated for high blood pressure as well as people without the chronic condition. The results of a meta-analysis do not prove that untreated ...

Stopping and reversing Alzheimer's at an early stage

TUM study shows promising therapeutic approach

19-Aug-2024 - In the fight against Alzheimer's, researchers at the Technical University of Munich (TUM) have developed a promising, preventative therapeutic approach. They specifically targeted the amyloid beta biomolecule, which triggers the hyperactivity of nerve cells typical of the brain disease in its ...

Alzheimer’s disease: It’s not only neurons – glial cells also produce harmful proteins

15-Aug-2024 - Memory loss, confusion, speech problems – Alzheimer’s disease is the most common cause of dementia, affecting about 35 million people worldwide, and the number is growing. The protein amyloid beta, which occurs naturally in the brain, plays a central role in the disease: It accumulates in ...