Rhythmic genomics - the yeast metronome and the walk of life

09-Apr-2009 - United Kingdom

New genome sequence information from the humble baker's yeast has revealed surprising variation in a set of genes that can be thought of as nature's oldest clock. In a paper published in Genome Research scientists show how ribosomal RNA genes that are essential to all Earth's organisms provide insight into how genomes maintain their integrity on their evolutionary journey.

Ribosomal RNA sequence changes have been ticking away like clockwork for over 3 billion years, maybe even pre-dating the origin of the DNA world itself. However, even the slightest changes in sequence of these genes can be fatal. It is vital to conserve the important genetic 'cogs' to make sure cells function correctly. However, significant changes do occur, contrary to expectation, and yet the yeast somehow still survives.

Furthermore, when two yeasts hybridise the clocks appear to re-set, apparently overwriting each others' rhythm and eliminating unwanted variations on the theme. This provides clues as to how key motifs are conserved and allows us to track the evolutionary history of hybrids.

Steve James, lead researcher at the Institute of Food Research (IFR), said "I have sequenced these genes to selectively identify yeast species for over 15 years and had no idea they would turn out to be so variable."

Rob Davey, computational biologist at the National Collection of Yeast Cultures (NCYC), said "we can use new computer techniques to model the changes mathematically and really get to grips with what orchestrates the variation in these important cell housekeepers."

Original publication: "Repetitive sequence variation and dynamics in the ribosomal DNA array of Saccharomyces cerevisiae as revealed by whole-genome resequencing"; Genome Res. 2009. 19: 626-635.

https://www.bionity.com/en/news/99529/rhythmic-genomics-the-yeast-metronome-and-the-walk-of-life.html