Ondine Demonstrates High Efficacy of Photodisinfection Technology Against Key Hospital Pathogen Pseudomonas aeruginosa

21-Nov-2007

Ondine Biopharma Corporation announced the conclusion of a preclinical program demonstrating high efficacy of its Photodisinfection technology against cultures and biofilms of Pseudomonas aeruginosa, one of the most dangerous hospital-acquired pathogens. This work provides important preclinical support for Ondine's photodisinfection programs for skin wounds, burn and outer ear infections.

"Our preclinical Pseudomonas program has evolved over the last two years, focusing on optimization of many photodisinfection parameters including dosing and formulation," said Dr. Nicolas Loebel, Chief Technology Officer, Ondine Biopharma Corporation. "Pseudomonas is extremely difficult to kill and occurs throughout hospital environments as an opportunistic pathogen. Our photodisinfection system has demonstrated 100% eradication of Pseudomonas aeruginosa in planktonic (free-floating) cultures, and in excess of 99.9% kills in biofilms. The data from the preclinical research supports our belief that our photodisinfection technology could provide significant benefits over conventional antipseudomonal therapies such as topical antibiotics or micronized silver.

"Pseudomonas is a Gram-negative bacterium living in biofilm colonies surrounded by a viscous alginate matrix, a protective strategy that works so well that Pseudomonas has even been found living in hospital disinfectant solutions. The bacterium is notorious for its resistance to antibiotics. The case fatality rate in Pseudomonas-infected patients hospitalized with cancer, cystic fibrosis, burns and wounds is as high as 50%. Our photodisinfection technology has proven highly effective at disrupting Pseudomonas biofilms and rapidly killing the causative bacteria in vitro. The eradication process does not upregulate bacterial resistance factors because the process is rapid, the kill rates are high, and killing occurs through disruption of surface membranes rather than internal metabolic processes. After launching Periowave(TM), our ground-breaking photodisinfection treatment for adult periodontal disease, our new product development efforts are being focused into nasal MRSA decolonization, disinfection of skin wounds and burns and treatment of external ear infections. The combination of wide therapeutic window, absence of resistance and treatment speed implies a potentially new paradigm in the treatment of these complex infections."

https://www.bionity.com/en/news/74735/ondine-demonstrates-high-efficacy-of-photodisinfection-technology-against-key-hospital-pathogen-pseudomonas-aeruginosa.html