Allon Therapeutics completes enrolment for Phase II Alzheimer's trial
The Company expects that the results from this trial will support further clinical development in pursuit of a treatment for Alzheimer's disease. The 150 subject Phase II trial is a multi-center, double-blind, randomized, placebo-controlled, multiple-dose study to evaluate the safety, tolerability and effect on cognitive function of AL-108 after 12 weeks of intranasal administration in patients with amnestic mild cognitive impairment, the precursor to Alzheimer's.
Allon's Alzheimer's program is unique in that AL-108 targets a fundamental underlying mechanism of neurodegenerative disease and impacts both of the classic hallmarks of Alzheimer's. The Company has established an extensive data-set showing the effects of AL-108 on neurodegeneration and, in particular, both amyloid plaques and neurofibrillary tangles the two pathologies most closely correlated with Alzheimer's disease. In 2006, over $4 billion was spent on approved drugs for Alzheimer's disease; these drugs have only a modest effect on symptoms of the disease.
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