Cytori Therapeutics Demonstrates Adipose Stem and Regenerative Cells Reduce Incidence of Arrhythmia after Heart Attacks
"In addition to the improved functional benefit consistently observed in preclinical heart attack studies, this data suggest adipose stem and regenerative cells are not associated with increased risk of arrhythmias," said Marc H. Hedrick, M.D., President of Cytori Therapeutics. "This is an important finding due to the reported incidence of arrhythmias observed in clinical cardiac cell therapies derived from alternate cell sources. Additionally, it further supports our evaluation of this novel treatment in human clinical trials, which we intend to initiate this year."
As part of this study, adipose stem cells or a saline control injection were administered into infarcted subjects. The improvement in ejection fraction, capillary density and perfusion defect were reported earlier. In addition to these measured parameters, heart rhythms were constantly monitored throughout the eight week study period. At no point during this time was a difference in irregular heart beats between both groups observed, indicating that cell treated animals do not show an increase in potentially fatal arrhythmias. On the contrary, at the end of the study period, an electrophysiologic stimulation that artificially induces arrhythmias showed a significant longer cycle length, a measure of the electrical activity controlling heart contractions, in the cell treated group, which is indicative of a more organized and stable heart rhythm compared to the control group.
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