Illumina To Conduct Large-Scale Genotyping For Uk-Based Research Groups Studying Molecular Basis Of Prostate Cancer
llumina, Inc. announced that it has signed a genotyping services agreement to support prostate cancer researchers funded by Cancer Research UK. Under the terms of the agreement, valued at nearly $7 million, Illumina's service group will conduct whole-genome genotyping (>550,000 single nucleotide polymorphisms, or SNPs, per sample) for at least 4,000 well-classified prostate patients and controls. A second phase will involve development of a custom, 12-sample BeadChip that will enable analysis of 24,000 SNPs per sample and be used to genotype at least 8,000 samples. Both phases will use Illumina's Sentrix® BeadChips and Infinium(TM) Assay with the option to employ related assay methods.
This is the second large-scale genotyping agreement signed between the two organizations in the last six months. Its structure closely follows a November 2005 agreement under which Illumina is genotyping colorectal cancer samples and controls for Cancer Research UK.
Illumina's genotyping services group will support work being driven scientifically by a collaboration comprising two Cancer Research UK-funded research groupings investigating the genetic basis of prostate cancer. One of the research groups is led by Dr. Rosalind Eeles of the Translational Cancer Genetics Team at The Institute of Cancer Research, London. The second research group will be led by Professor Douglas Easton in Cancer Research UK's Genetic Epidemiology Unit in the Strangeways Research Laboratory at the University of Cambridge. The aim of the work is to investigate the role of common genetic variation in the etiology of prostate cancer. From the work, it is hoped that it will be possible in the future to design and validate biomarkers associated with prostate cancer susceptibility and disease progression, as well as to facilitate development of improved therapeutic approaches.
Other news from the department science
