BioFocus collaborates with Cresset to develop new range of compound libraries
BioFocus, Galapagos' services division, announced that is has formed an alliance with Cresset BioMolecular Discovery Limited (Cresset BMD) to develop a new range of compound libraries. BioFocus is developing this new range of "FieldFocus(TM)" compounds based on Cresset's molecular fields software. BioFocus also has an option to license the technology for medicinal chemistry projects for itself and third parties.
While conventional modelling approaches rely on the atom and bond representations of compounds, Cresset's FieldTemplater(TM) method of molecular field modelling identifies the molecular field of the 3-dimensional conformation of a compound. This provides a powerful "protein's view" of the key molecular features required for biological activity. Furthermore, using molecular field patterns to compare molecules enables a robust structure-independent method of identifying novel chemical classes that can take a project into new intellectual property space. This technology is especially valuable for certain classes of receptors such as GPCR and ion channels, which are highly valued by the pharmaceutical industry but which lack sufficient X-ray crystallographic structures to allow easy molecular design.
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