Matritech Presents Improved Method for Detecting the NMP66(TM) Complex in the Blood of Women with Breast Cancer
Matritech presented an improved method of detecting the NMP66(TM) nuclear matrix protein complex in serum from women with breast cancer. Matritech scientists have developed several methods to detect the NMP66 complex in serum including an immunoassay and a Reverse Transcriptase-Polymerase Chain Reaction (RT-PCR) procedure. The scientists have continued to work on assay optimization including the development of methods to increase the sensitivity of the immunoassay.
The new concentration method employed an anti-sense affinity capture (AAC) procedure. The AAC method was used in a proof of concept study comparing samples from women with no breast disease to women with breast cancer. After the samples underwent the AAC concentration step, they were tested by RT-PCR. In a cohort of eight specimens, the NMP66 complex was found in each cancer patient and was absent in each of the healthy subjects. Matritech scientists plan to test additional samples using the combination of the AAC-concentration method and the NMP66 immunoassay.
The NMP66 breast cancer program in development is based on Matritech's proprietary nuclear matrix protein (NMP) technology. NMPs comprise the protein framework that organizes DNA inside the cell. They change in amount in cancerous cells, making them excellent markers for a variety of cancers. NMPs are found in body fluids, are highly accurate and can be detected in a minimally invasive manner. Matritech scientists, using a research mass spectrometer, discovered the existence of certain proteins (NMP66) in the blood of breast cancer patients that were generally not present in the blood of women without detectable breast malignancy.
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Topic World Spectroscopy
Investigation with spectroscopy gives us unique insights into the composition and structure of materials. From UV-Vis spectroscopy to infrared and Raman spectroscopy to fluorescence and atomic absorption spectroscopy, spectroscopy offers us a wide range of analytical techniques to precisely characterize substances. Immerse yourself in the fascinating world of spectroscopy!