Genizon and Institute for Clinical Molecular Biology Replicates Disease Gene Discoveries in Crohn's Disease

Results Confirm the Power of Genizon's Platform and the Quebec Founder Population for Disease Gene Discovery

26-Oct-2005

Genizon Biosciences and the Institute for Clinical molecular biology, University Hospital Schleswig-Holstein announced the replication of many disease gene signals for Crohn's disease, previously discovered by Genizon in the Quebec Founder Population. This replication further confirms the validity of Genizon's methods and the applicability of Genizon's discoveries to general populations, and underscores the power of the Quebec Founder Population in the discovery of disease genes.

A selection of narrowly defined candidate regions, previously announced by Genizon from a whole genome association study on Crohn's disease, was fine mapped using samples from a German population, collected by a group led by Professor Stefan Schreiber, Director of the Institute for Clinical Molecular Biology. These regions have led to a comprehensive GeneMap for Crohn's disease, consisting of multiple interacting genes, biochemical pathways and prospective targets for therapeutic intervention.

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