Genomic instability and premature aging
In Nature Medicine Online researchers at Karolinska Institutet and the University of Hong Kong describe this enzyme's importance for the stability of DNA. The results indicate that mutations in prelamin A and lamin A perturb DNA damage response and repair, resulting in genomic instability which might contribute to certain types of premature aging.
Original publication: B. Liu , J. Wang, K. M. Chan, W. M. Tjia, W. Deng, X. Guan, J. Huang, K. M. Li, P. Y. Chau, D. J. Chen, D. Pei, A. M. Pendas, J. Cadinanos, C. Lopez-Otin, H. F. Tse, C. Hutchinson, J. Chen, Y. Cao, K. S. E. Cheah, K. Tryggvason, Z. Zhou; " Genomic instability in laminopathy-based premature aging"; Nature Medicine Online 26 June, 2005.
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