Viragen Reports Advancement in Avian Transgenics Biomanufacturing
Anti-cancer Antibody Expressed in Rooster
Viragen, in collaboration with Roslin Institute and Oxford Biomedica PLC, reported that an antibody designed to treat malignant melanoma (anti-GD3 antibody) has been successfully detected in the blood of a founder transgenic rooster after the antibody was introduced using a proprietary gene delivery system. This achievement is the first in a series of steps designed to confirm that a humanized antibody can be produced in subsequent generations of chickens and demonstrate a fully intact structure capable of its intended therapeutic function.
Project Leader, Roslin's Dr. Helen Sang, explained, "We have previously demonstrated that a reporter gene can be synthesized in the oviduct of laying hens, the source of egg white proteins. The significance of this new milestone is that we are now using a humanized anti-cancer antibody, which has been incorporated into the bird's DNA."
In other avian transgenic-related news, it was announced that a scientific article has been published in Drug Discovery Today (Volume 10, Number 3, February 2005). The article, titled "Transgenic chickens as bioreactors for protein-based drugs", reports on significant advances to develop avian transgenics.
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