LI-COR Odyssey System Used for Imaging Animal Models of Alzheimer's Disease
Lincoln. The LI-COR Odyssey(R) Infrared Imaging System is being used as a detection platform for non-invasive screening of senile plaques in mice. Dr. Brian Bacskai and Jesse Skoch, researchers at Massachusetts General Hospital, are using the Odyssey System in their study of Alzheimer's disease.
In a paper detailing their research, the investigators note they used the Odyssey to capitalize on the two near infrared fluorescent channels the instrument provides. The researchers wanted to show that deep tissue detection of fluorescence within living animals is possible noting that the Odyssey has several advantages over positron emission tomography (PET). "The advantages of near infrared detection for non-invasive animal imaging are well documented," says Jim Wiley, LI-COR product marketing manager. "We are excited to see how the Odyssey is able to contribute to the understanding of such a devastating disease as Alzheimer's." Wiley adds, "a fundamental mission of our company is to provide tools to researchers that help in the quest to improve the quality of life."
The paper is available at http://www.licor.com/mouse.
The Odyssey Infrared Imaging System is uniquely equipped with two infrared channels for direct fluorescence detection on membranes with sensitivity that is equal to or better than chemiluminescence. The superior signal-to-noise ratio produced by the near infrared dyes produces results not possible with traditional fluorescence-based imaging systems.
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