Cell Therapeutics' subsidiary PanGenex introduces technology for high-throughput, cell-based screening of new cancer targets
Technology described at international scientific conference
PanGenex, Inc. (PanGenex) presented data on its gene knockout, gene expression reporter, and siRNA technologies at the International Conference on Molecular Targets and Cancer Therapeutics jointly sponsored by the American Association for Cancer Research (AACR), the National Cancer Institute (NCI), and the European Organization of Research and Treatment of Cancer (EORTC).
PanGenex has generated a gene library of over 50,000 gene sequences and vectors that enable efficient production of gene expression reporters and gene knockouts in human cells. The library which currently contains about 1/3 of all human genes, and includes known drug targets as well as numerous genes implicated in human diseases by genomics and proteomics. The PanGenex library can be used to efficiently make reporter constructs and knockouts in human tumor cell lines and immortalized primary cells. Gene expression reporter cells are amenable for high throughput, cell-based assays for screening chemical diversity libraries for drug candidates. As an example of the utility of this technology, PanGenex scientists presented the use of gene expression reporter cells to screen siRNA reagents to identify key pathways and genes associated with cancer. The company identified a gene referred to as PGXA001 D3 whose expression is increased in response to TGF-alpha and IGF-1, both of which have been implicated in maintenance of cancer. By screening a library of siRNA reagents, the pathways and genes implicated in regulation of PGXA001 D3 were identified.
"The ability to produce custom gene expression reporter cells with any gene in the extensive PanGenex gene library in relevant human cell lines allows us to link gene data from genomics and proteomics with cell-based assays for drug discovery. By screening chemical diversity libraries and siRNA libraries, the technology allows simultaneous identification of both chemical compounds that are the starting point for drug development as well as pathways and new drug discovery targets and biomarkers," states Robert Finney, Ph.D., president of PanGenex.
Other news from the department business & finance
These products might interest you
Micro-Dx™ CE IVD by Molzym
Fully automated from sample to PCR analysis
Rapid identification of bacteria and fungi without time-consuming cultivation
DNA-free Taq Polymerases and Mastermixes by Molzym
DNA-free reagents for unrivalled sensitivity in molecular biology
Purity that makes the difference
Greener Alternative Products by Merck Life Science
Sustainable laboratory products for environmentally conscious research
Over 2,500 ecological alternatives to reduce your laboratory footprint
CellGenix® Growth Factors and Cytokines by Sartorius
Recombinant growth factors without animal products
Optimised cell culture for T cells and MSCs in gene therapy
Recombumin® Elite by Sartorius
ICHQ7 cGMP-compliant albumin for biotechnological applications
Increase consistency and safety for gene therapies and vaccines
DNA/RNA Shield™ SafeCollect Collection Kits by Zymo Research
Sample collection devices for simple & safe at-home testing
Best user experience for secure self-collection
Get the life science industry in your inbox
From now on, don't miss a thing: Our newsletter for biotechnology, pharma and life sciences brings you up to date every Tuesday and Thursday. The latest industry news, product highlights and innovations - compact and easy to understand in your inbox. Researched by us so you don't have to.
Most read news
More news from our other portals
See the theme worlds for related content
Topic World Cell Analysis
Cell analyse advanced method allows us to explore and understand cells in their many facets. From single cell analysis to flow cytometry and imaging technology, cell analysis provides us with valuable insights into the structure, function and interaction of cells. Whether in medicine, biological research or pharmacology, cell analysis is revolutionizing our understanding of disease, development and treatment options.
Topic World Cell Analysis
Cell analyse advanced method allows us to explore and understand cells in their many facets. From single cell analysis to flow cytometry and imaging technology, cell analysis provides us with valuable insights into the structure, function and interaction of cells. Whether in medicine, biological research or pharmacology, cell analysis is revolutionizing our understanding of disease, development and treatment options.
