Improving therapies for GI tumors
Using in vitro and in vivo models of upper gastrointestinal cancers, the investigators found that AURKA activates EIF4E (protein translation initiation factor) and cap-dependent translation and increases levels of the cancer-associated factor c-MYC.
Targeting AURKA genetically or with the small molecule inhibitor alisertib reversed these molecular events, reduced cancer cell survival in vitro and induced in vivo tumor regression of upper gastrointestinal cancer models that are resistant to the mTOR inhibitor everolimus.
In their report the researchers propose targeting AURKA as a novel therapeutic strategy to treat tumors resistant to mTOR inhibitors and those that have activation of EIF4E and c-MYC.
Original publication
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