Breakthrough in understanding of the mechanisms of pancreatic cancer

26-Feb-2016 - Canada

pancreatic cancer carries a very bleak prognosis for patients. However, a recent breakthrough by two research teams, including one at the Hôpital Maisonneuve-Rosemont (CIUSSS-EST, Montreal) and University of Montreal, has opened the door to a better understanding of the molecular mechanisms that cause this cancer to develop.

This biomedical research conducted jointly by the groups of Dr. Frédérick Antoine Mallette (Université de Montréal / Centre de Recherche HMR) and Dr. Stéphane Richard (McGill University / Lady Davis Institute for Medical Research) has shown that pancreatic tumours often lose the ability to express a small ribonucleic acid molecule called miR-137. This molecule induces a defence mechanism called cellular senescence, which keeps cancer cells in check. The loss of miR-137 works in conjunction with various mutations frequently observed in pancreatic tumours to trigger uncontrolled cell growth and then cancer.

"It is essential that we better understand the mechanisms that lead to the loss of miR-137 expression. Once we do, we can create therapeutic strategies to treat and prevent pancreatic cancer," said Dr. Frédérick Antoine Mallette.

This joint research study by doctoral student Mathieu Neault has also demonstrated that restoring normal miR-137 levels in pancreatic cancer cells has a protective effect, as doing so induces senescence and stops the cells from spreading.

Original publication

Mathieu Neault, Frédérick A. Mallette, Stéphane Richard; "miR-137 Modulates a Tumor Suppressor Network-Inducing Senescence in Pancreatic Cancer Cells"; Cell Reports; 2016

https://www.bionity.com/en/news/157027/breakthrough-in-understanding-of-the-mechanisms-of-pancreatic-cancer.html

Original publication

Mathieu Neault, Frédérick A. Mallette, Stéphane Richard; "miR-137 Modulates a Tumor Suppressor Network-Inducing Senescence in Pancreatic Cancer Cells"; Cell Reports; 2016

Topics

pancreatic cancer cellular senescence

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