Researchers develop new nanoparticle with potential to treat ocular cancer

22-Feb-2016 - USA

Researchers at the University of Michigan Kellogg Eye Center have developed a new nanoparticle that uses a tumor cell's protective mechanism against itself -- short-circuiting tumor cell metabolism and killing tumor cells.

"Our work uses a semiconducting nanoparticle with an attached platinum electrode to drive the synthesis of an anti-cancer compound when illuminated by light," says Howard R. Petty, Ph.D., professor of ophthalmology and visual sciences and of microbiology and immunology. "The nanoparticle mimics the behavior of NADPH oxidase, an enzyme used by immune cells to kill tumor cells and infectious agents. Since tumor cells typically use NADPH to protect themselves from toxins, the more NADPH they synthesize for protection, the faster they die."

In a four-year study conducted on the mouse model in advanced breast cancer metastasis in the eye's anterior chamber, Petty and colleagues found that the new nanoparticle not only killed tumor cells in the eye, but also extended the survival of experimental mice bearing 4T1 tumors, a cell line that is extremely difficult to kill. "Previous monotherapies have not extended the lifetimes of mice bearing this type of tumor," Petty said. "Our work has shown that we can extend survival of the mice."

"This treatment offers many advantages," Petty says. "The nanoparticle produces about 20 million toxins per hour in each cell. Also, the nanoparticle is activated by light, so it can be turned on and off simply by exposing it to the correct color of visible light."

This nanotechnology also has the potential to be used for multiple applications in ophthalmology and other disciplines.

Original publication

Other news from the department science

These products might interest you

Eclipse

Eclipse by Wyatt Technology

FFF-MALS system for separation and characterization of macromolecules and nanoparticles

The latest and most innovative FFF system designed for highest usability, robustness and data quality

DynaPro Plate Reader III

DynaPro Plate Reader III by Wyatt Technology

Screening of biopharmaceuticals and proteins with high-throughput dynamic light scattering (DLS)

Efficiently characterize your sample quality and stability from lead discovery to quality control

particle analyzers
Loading...

Most read news

More news from our other portals

So close that even
molecules turn red...