Candidate genes were discovered utilizing microbial database and dedicated computational platform

10-Aug-2015 - Israel

Evogene Ltd. announced a key milestone in its insect control program with the successful completion of the first computational discovery round for microbial genes with insecticidal properties. The discovery round utilized a unique computational technology infrastructure consisting of a proprietary microbial-based database and a dedicated analysis platform, BiomeMiner^TM. The candidate genes will be validated against target insects at the Company's dedicated R&D site. Validation is expected to be completed next year.

The first computational discovery round yielded a set of novel candidate genes with insecticidal properties to be validated against Coleoptera and Lepidoptera insects. These families of insects include some of the most devastating insects to crop yields such as corn rootworm and corn earworm.

When inserted into a target crop, these genes and their insecticidal traits provide protection for the plant from certain harmful insects. Today, most of these products are based on microbial genes derived from one type of bacteria, named Bacillus thuringiensis (Bt), to which insects have grown resistant over the years. The next generation of insect control products that will address this growing resistance will most probably be based on the discovery of microbial genes not derived from the Bt bacteria. With the microbial gene pool constituting hundreds of millions of potential genes, the challenge of finding novel microbial genes that can form the basis of future insect control products, depends on both compiling the huge amount of relevant data into one integrated database and successfully analyzing this huge diversity.

https://www.bionity.com/en/news/154014/candidate-genes-were-discovered-utilizing-microbial-database-and-dedicated-computational-platform.html