Cardiff scientists bid to develop anthrax vaccine to counteract world bioterrorism threat
It is the growing concern over the threat posed by bioterrorism that has prompted world authorities like NATO through its Science for Peace and Security Programme to support efforts to develop more effective vaccines and medical countermeasures.
Efforts have so far been hampered by the fact that cases of naturally acquired human infection are rare in NATO countries. As a consequence, researchers have been forced to employ animal models to develop new vaccines.
The problem with this approach is the immune responses of animals and humans differ and as a consequence human clinical trials represent an essential element in confirming the efficacy of any new vaccine.
Such trials require access to several thousand volunteers at risk of infection and as such would be almost impossible to perform in Western Europe or the US.
In contrast anthrax represents a significant disease of animals and humans in the Cacuses and Central Asia. For this reason researchers from the UK and US have joined with colleagues from Turkey and the former Soviet republic of Georgia to tackle the problem.
Professor Baillie added: "These unique resources, combined with the expertise of NATO researchers offers us an unparalleled opportunity."
The outputs of this study are expected to underpin the development of future vaccines capable of conferring broad-spectrum, robust protection following minimal dosing.
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