ProtAffin AG announces preclinical data in Multiple Sclerosis for MCP-1 decoy program
ProtAffin AG announced preclinical data on its MCP-1 decoy program in a model of multiple sclerosis at the ECTRIMS/ACTRIMS conference.
The Company presented a poster on its MCP-1 decoy program at the Immunomodulation session at the ECTRIMS/ACTRIMS conference, which is the 5th Joint Triennial Congress of the European and Americas Committees for Treatment and Research in Multiple Sclerosis. The Company presented in vivo efficacy data of the glycan-binding MCP-1 decoy protein PA508 in a model of experimental autoimmune encephalomyelitis (EAE), a gold-standard preclinical model of Multiple Sclerosis. PA508 showed a significant improvement in the clinical score over 28 days, as well as histology in the CNS, with PA508 showing a reduction in inflammatory infiltrates and preservation of myelin structures in the spinal cord and cerebellum.
Prof. Andreas Kungl, CSO of ProtAffin commented: “We are excited by these data which indicates that Multiple Sclerosis is an additional therapeutic opportunity for this second program at ProtAffin, in addition to previously published data of PA508 in murine models of myocardial infarction, restenosis and autoimmune uveitis. It furthermore underlines the ability to efficiently generate multiple product candidates from ProtAffin’s proprietary CellJammer® discovery technology. As we move our lead program, the IL-8 decoy PA401 into Phase 1 Q2 2012, we aim to establish the innovative therapeutic concept of biopharmaceuticals targeting glycans as a novel modality to optimally down-regulate proteins that bind glycans.”
Most read news
Organizations
Other news from the department research and development

Get the life science industry in your inbox
By submitting this form you agree that LUMITOS AG will send you the newsletter(s) selected above by email. Your data will not be passed on to third parties. Your data will be stored and processed in accordance with our data protection regulations. LUMITOS may contact you by email for the purpose of advertising or market and opinion surveys. You can revoke your consent at any time without giving reasons to LUMITOS AG, Ernst-Augustin-Str. 2, 12489 Berlin, Germany or by e-mail at revoke@lumitos.com with effect for the future. In addition, each email contains a link to unsubscribe from the corresponding newsletter.
More news from our other portals
Last viewed contents
Daboia
Adenorhinos
Oncolytics Biotech Inc. Successfully Completes Initial Scale Up of Manufacturing Process for REOLYSIN
