New clinical and preclinical data on Basilea's novel antibiotic BAL30072 against multidrug-resistant Gram-negative superbugs

21-Sep-2011 - Switzerland

Detailed results from the successful first phase I study with Basilea's novel antibiotic BAL30072 were presented at the 51st Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) in Chicago, USA. Additional preclinical data underline the strong bactericidal activity and broad coverage of BAL30072 against clinically-relevant multidrug-resistant Gram-negative bacteria. Also, further data on Basilea's anti-MRSA broad-spectrum antibiotic ceftobiprole are presented.

Multidrug-resistant Gram-negative bacteria such as Pseudomonas aeruginosa and Acinetobacter baumannii are causing growing concern as they have become resistant to most marketed antibiotics, leaving only few or no therapeutic options.

Basilea's BAL30072, a beta-lactam antibiotic of the sulfactam class, has the potential to play an essential role in the therapy of life-threatening infections caused by such multidrug-resistant as it is not easily destroyed by bacterial enzymes which cause resistance against many currently marketed antibiotics. BAL30072 has demonstrated bactericidal activity against a broad range of Gram-negative superbugs.
BAL30072 - a novel sulfactam antibiotic against multidrug-resistant Gram-negative bacteria

Favorable data from the first phase I study, a double-blind, randomized, placebo-controlled, single ascending dose study demonstrate the excellent safety profile of BAL30072. In the study, no clinically relevant drug-related adverse events were observed at any dose level and no dose-limiting toxicities were identified. BAL30072 displayed predictable linear pharmacokinetics with low inter-subject variability, in line with preclinical data and in accordance with the favorable beta-lactam class profile. (Posters A2-572, F1-145 and F1-146) A second, multiple ascending dose phase I study with BAL30072 has been recently initiated and is anticipated to be completed in the first part of 2012.

https://www.bionity.com/en/news/134463/new-clinical-and-preclinical-data-on-basilea-s-novel-antibiotic-bal30072-against-multidrug-resistant-gram-negative-superbugs.html