Carl Zeiss Obtains Licence from University of California for Illumination Technique

25-Jul-2011 - Germany

Carl Zeiss has received a licence from the University of California in San Francisco (UCSF) for the commercialization of “Multidirectional Selective Plane Illumination Microscopy” (mSPIM), an advanced illumination technique for light sheet fluorescence microscopy.

Light sheet fluorescence microscopy is a relatively new application of the concept of light sheet illumination in biology and the life sciences. It is ideally suited for live imaging of up to millimeter sized fluorescently labeled specimens for days under certain physiological conditions and with minimum photo-induced damage.

The mSPIM technique was developed by Dr. Jan Huisken at the UCSF. It reduces absorption and scattering artifacts and provides an evenly illuminated focal plane. By alternating illumination of the sample from multiple sides, mSPIM overcomes two common problems in light sheet imaging techniques: shadowing effects in the excitation path and spreading of the light sheet by scattering in the sample.

The agreement grants Carl Zeiss the right to integrate the mSPIM technology in its microscopy systems. The first commercial light sheet fluorescence microscope (LSFM, also known as “selective plane illumination microscope” or “SPIM”) for multidimensional, ultrafast and long- term timelapse imaging of live specimens is currently being developed at Carl Zeiss in Germany.

Other news from the department business & finance

Most read news

More news from our other portals

Is artificial intelligence revolutionizing the life sciences?

See the theme worlds for related content

Topic world Fluorescence microscopy

Fluorescence microscopy has revolutionized life sciences, biotechnology and pharmaceuticals. With its ability to visualize specific molecules and structures in cells and tissues through fluorescent markers, it offers unique insights at the molecular and cellular level. With its high sensitivity and resolution, fluorescence microscopy facilitates the understanding of complex biological processes and drives innovation in therapy and diagnostics.

5 products
1 whitepaper
5 brochures
View topic world
Topic world Fluorescence microscopy

Topic world Fluorescence microscopy

Fluorescence microscopy has revolutionized life sciences, biotechnology and pharmaceuticals. With its ability to visualize specific molecules and structures in cells and tissues through fluorescent markers, it offers unique insights at the molecular and cellular level. With its high sensitivity and resolution, fluorescence microscopy facilitates the understanding of complex biological processes and drives innovation in therapy and diagnostics.

5 products
1 whitepaper
5 brochures

Last viewed contents

Canbex Therapeutics receives £1.75 million Translation Award from the Wellcome Trust

Aseptika Granted United States Patent for Biomarkers for Respiratory Infection Onset

A new mechanism protects against cancer cell migration and neuron hyperexcitability

A new mechanism protects against cancer cell migration and neuron hyperexcitability

Lab901 and Biofortuna to collaborate on automated PCR Dx for HLA and Coeliac disease

Asterion Raises £355k Funding to Progress Novel Therapies for Hormone Related Diseases

Evogene and Zeraim Gedera Salt Tolerant Tomato Collaboration Advances to Second Phase

Heptares granted patents covering stabilised receptor technology in Europe and Japan - Key patent grants protect Heptares’ leading position in GPCR-targeted drug design and discovery

Pevion’s therapeutic Candida vaccine shows robust systemic and mucosal immunogenicity

Covestro and Genomatica produce important chemical raw material using biotechnology - Breakthrough for HMDA, widely-used ingredient, paves the way for more sustainable coatings, apparel, adhesives and plastics

Covestro and Genomatica produce important chemical raw material using biotechnology - Breakthrough for HMDA, widely-used ingredient, paves the way for more sustainable coatings, apparel, adhesives and plastics

Amarin corporation Appoints Colin W. Stewart as President and Chief Executive Officer

Discovery of quantum vibrations in 'microtubules' corroborates theory of consciousness

Merck Expands Corporate Venture Fund M Ventures with a New Investment of € 600 Million - “Over the past decade, M Ventures has established itself globally as a leading partner to the biotech and tech venture ecosystems”

Merck Expands Corporate Venture Fund M Ventures with a New Investment of € 600 Million - “Over the past decade, M Ventures has established itself globally as a leading partner to the biotech and tech venture ecosystems”