Applying quantitative proteomics to tumor marker discovery
Tumor diagnostics is hampered by the extremely low abundance of tumor markers in blood serum. Techniques for detecting such markers must therefore be fine-tuned to reach a very high level of sensitivity. In the project, Entelechon will develop a kit which allows to deplete abundant proteins, such as immunoglobulines or albumin, in a serum sample, and to specifically enrich target marker proteins.
A consortium of four partners: The Institute for Pathology and the Surgical Clinic of the University Medical Center Erlangen, the Biobank of the University Cancer Center Erlangen, the Institute for Biochemistry of the Friedrich-Alexander-University Erlangen-Nürnberg, and Entelechon. The Institute for Biochemistry will contribute mass spectrometry expertise and the development of analytical protocols, while the clinical partners will contribute expertise on tumor markers, as well as serum samples of healthy subjects and patients.
With this project, Entelechon continues its successful activities in the field of tumor diagnostics, which had started with the participation in the DECanBio consortium. DECanBio aims at identifying biomarkers for bladder cancer in urine.
The project will provide new approaches and answers for R&D laboratories and pharma companies working on the validation of biomarkers for drug development. The kit will also be a foundation for other products for the parallel detection of multiple biomarkers in cancer and other diseases.
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Topic world Diagnostics
Diagnostics is at the heart of modern medicine and forms a crucial interface between research and patient care in the biotech and pharmaceutical industries. It not only enables early detection and monitoring of disease, but also plays a central role in individualized medicine by enabling targeted therapies based on an individual's genetic and molecular signature.
Topic world Diagnostics
Diagnostics is at the heart of modern medicine and forms a crucial interface between research and patient care in the biotech and pharmaceutical industries. It not only enables early detection and monitoring of disease, but also plays a central role in individualized medicine by enabling targeted therapies based on an individual's genetic and molecular signature.