Galapagos initiates second Proof of Mechanism clinical study in GSK alliance
Phase I study measures effect on biomarker in healthy volunteers
Galapagos plans to conduct the multiple ascending dose study in 45 healthy volunteers using five two-week dosing regimens. In this Proof of Mechanism study, GPLG0778's ability to suppress an induced inflammatory response in healthy volunteers will be evaluated. In addition to measuring the biomarker response, the safety, tolerability and pharmacokinetics of candidate drug GLPG0778 will be assessed further. Galapagos aims to report the study results in the fourth quarter of 2011. GSK has an exclusive option to in-license this compound.
"With the initiation of this study, we could demonstrate clinical proof of mechanism for GLPG0778 this year," said Onno van de Stolpe, CEO of Galapagos. "Together with two other compounds in development, we have multiple programs capable of delivering in the immuno-inflammation alliance with GSK."
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