Astex Announces Commencement of Phase I Study for AZD5363 in Anti-Cancer Collaboration with AstraZeneca
AZD5363 is an orally active selective inhibitor of PKB/Akt, a key enzyme in the PI3K/PKB/mTOR tumour cell survival pathway, and dysregulation of this pathway leads to tumour resistance to a number of important anti-cancer drugs. Inhibition of PKB/Akt has potential in the treatment of a broad range of cancer types.
The Phase I study, being conducted at multiple centres in Europe, is designed to investigate the safety, tolerability and preliminary anti-cancer activity of AZD5363 in patients with advanced solid tumours, and to identify a dose and schedule that can be used in Phase II trials.
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