Another Patent Licensed for PAL-M Super-resolution Technology
Together with the previously issued patents (U.S. 7,626,694, U.S. 7,828,695, U.S. 7,626,703 and U.S. 7,782,457) substantial systems and methods of super-resolution microscopy are now protected. These methods are based on the separation and localization of molecules to achieve resolution beyond the Abbe resolution limit.
U.S. Patent 7,864,314, published January 4 2011, expands the patent protection to systems and methods utilizing separation by photo-optical transformation of molecules between different energy states. For example, only a few molecules can be activated from a dark state and then localized, or almost all molecules can be transformed into a dark state and the few remaining ones are localized.
This technology expands the ways in which classical dyes can be used for applications in super-resolution microscopy.
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