Lead Discovery Center and Merck KGaA Enter Collaboration for the Discovery of Anti-Cancer Compounds
Research collaboration may realize the potential of kinase inhibitors as a means for cancer treatments in the future
The Lead Discovery Center GmbH (LDC), a small molecule drug discovery spin-off of Max Planck Innovation GmbH, announced that it has signed a cooperation agreement with Merck KGaA for the discovery of kinase inhibitors as potential cancer treatments.
The collaboration is supported by the German Ministry of Education and Research (BMBF) under the BioPharma initiative to strengthen the pharmaceutical value chain in Germany.
Using an innovative kinase technology platform originating from the Chemical Genomics Centre of the Max Planck Society (CGC, Dortmund), Merck Serono, a division of Merck KGaA, and the LDC aim to identify inhibitory compounds against at least one undisclosed kinase target and advance them through the drug discovery process up to pharmaceutical lead compounds.
Kinases are key components of biochemical signalling pathways that control cellular growth, metabolism and differentiation. They have therefore become prime targets for drug discovery and development in many diseases, especially in oncology. “Our proprietary technology allows for the identification of innovative allosteric kinase inhibitors that hold strong potential for improved potency and selectivity,” says Prof. Dr. Daniel Rauh, group leader at the CGC. “We are excited about the alliance between the LDC and Merck Serono as it provides us with the unique chance to translate our approach into application.”
Under the terms of the agreement, the LDC and Merck Serono will work closely together, with each partner contributing its particular expertise and infrastructure as well as their own resources in the fields of assay development, screening, medicinal chemistry and pharmacology.
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