AGILENT TECHNOLOGIES INTRODUCES MULTISIGNAL OUTPUT ACCESSORY FOR EASIER PHARMACEUTICAL DEVELOPMENT AND QA/QC
Easing the Regulatory Burden
Pharmaceutical companies operate under strict compliance regulations as mandated by the FDA in the United States and equivalent governing bodies around the world. These regulations become more stringent as candidate drugs move further along the development pipeline where quantitative data is required to support new drug applications. Many development laboratories use mass spectrometry (MS) for quantification of new drugs and their metabolites in efficacy and safety/toxicity studies. To meet regulatory requirements, the data system that quantifies the data must be validated. Agilent’s multisignal output accessory lessens the expensive task of validating multiple data systems in laboratories with multiple mass spectrometers by converting the unprocessed digital MS signals to analog format and transmitting them directly to the pharmaceutical company’s LIMS system. Calculations are then done on the LIMS system, so only the LIMS system would require extensive and costly validation.
Outstanding Data Handling Flexibility
The multisignal output accessory is a free-standing box. It communicates with the LC/MSD using a 10BaseT local area network (LAN), so it can be located remotely from the mass spectrometer.
The multisignal output accessory can process up to 12 input signals from an LC/MSD. An input signal can be a total ion chromatogram (TIC) signal or a selected ion monitoring (SIM) signal. The multisignal output accessory also has 12 D/A output channels. Each output channel can accommodate a TIC signal, an individual SIM ion signal, or the sum of up to 11 SIM ion signals.
Each output channel also has a configurable switch closure that may be configured for a simple SPST normally open switch or TTL enabled. Each channel has a front panel LED to indicate data activity. The maximum abundance of each output channel can be individually set in the range of 10 K to 16 M counts. The full-scale output voltage may be selected as 1 volt or 10 volts to accommodate different LIMS input limitations.
U.S. Pricing and Availability
The price of the Agilent G1979A multisignal output accessory will be approximately $9,500. Shipments are expected to start in September 2002.
Information about Agilent’s life science products and services is available at www.agilent.com/chem .
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