Santhera Licenses Melanocortin-4 Receptor Antagonist Program to BioLineRx
19-Oct-2010
- Switzerland
The preclinical activity spectrum of orally active MC-4R antagonists indicates beneficial efficacy in all key aspects of cachexia such as lack of appetite, increased resting energy expenditure and enhanced catabolism. The latest generation of compounds increased food intake 3- to 5-fold and inhibited the development of cachexia in a disease-relevant animal tumor model.
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