Stallergenes and Shionogi Sign Exclusive Partnership Agreements for Immunotherapy Tablets in Japan
Stallergenes S.A. has announced the signing of exclusive partnership agreements with Shionogi & Co., Ltd. for two sublingual allergen immunotherapy tablet products resulting from the Stalair(R) program: Actair(R) house dust mite tablets and Japanese cedar pollen tablets.
With 32 million respiratory allergy sufferers, there is a strong demand for treatment in Japan, where sublingual allergen immunotherapy is currently not available. House dust mites and Japanese cedar pollen are the two main causes of respiratory allergies and the Japanese cedar allergy is a major public health concern in the country. This partnership is the first of its kind in Japan and will bring sublingual immunotherapy to patients suffering from severe allergic rhinitis, inadequately controlled using symptomatic treatments (antihistamines, corticosteroids).
The agreement covers the development, registration, promotion and distribution of Actair(R) in Japan and Taiwan, and of the Japanese cedar pollen tablet in Japan. The clinical development of Actair(R) will be launched in 2011 in order to prepare the license application. For the Japanese cedar pollen tablet, a specific development plan will be initiated through close collaboration between the two partners, since the product is exclusively aimed at the Japanese market.
Stallergenes will receive an immediate upfront payment of Euros 24 million, up to Euros 46 million in development and regulatory milestones payments, as well as sales milestones. Furthermore, Stallergenes will be entitled to royalty payments on net sales of the products by Shionogi & Co., Ltd.
Shionogi & Co., Ltd. will be responsible for the clinical development, registration, marketing and sales of the products covered by this agreement in Japan. Stallergenes will be responsible for tablet production and supply, and early-stage development.
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