Probiodrug Obtains Additional US Patent for the Inhibition of the Enzyme Glutaminyl Cyclase (QC) to Treat CNS Diseases
Probiodrug AG announced that Probiodrug has been granted US patent no. 7,732,162 covering additional subject matters for the company's QC inhibitors by the United States Patent Office. The patent comprises the use of QC inhibitors to treat mild cognitive impairment, neurodegeneration in Down syndrome, Familial British and Familial Danish dementia and the use of QC inhibitors to treat these diseases, as well as Alzheimer's disease, in combination with additional agents. These agents comprise, among others, beta amyloid antibodies, acetylcholinesterase (AChE) inhibitors, beta secretase inhibitors, and gamma secretase inhibitors.
„This is an important step to expand our patent estate around QC inhibition as a novel treatment paradigm in Alzheimer’s disease and other CNS diseases“, said Hans-Ulrich Demuth, CSO and co-founder of Probiodrug. „It extends our IP on QC inhibitor treatments to CNS diseases other than Alzheimer's and also to combination treatments, in which QC inhibitors are used alongside other compounds already marketed or under development.“
„Our patent estate now has grown to more than 35 patent families for QC inhibitors, including claims for composition of matter, formulations, and methods of treatment in various indications”, commented Matthias Hoffmann, VP Legal and Intellectual Property. „We have already been granted four patents in the US: one is the world's first patent covering broad methods to treat sporadic Alzheimer's disease using QC inhibitors, while the others cover QC inhibitors and the use of QC inhibitors in methods to treat CNS diseases such as Familial Alzheimer's diseases.“
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