Starting of the European project REBORNE aiming at bone defects regeneration using stem cells and biomaterials
Bone is the most frequently transplanted human tissue with about one million procedures annually in Europe. Either autologous or allogeneic bone grafts are primary used by orthopedic or maxillofacial surgeons to reconstruct large bone defects. However, these bone grafts have drawbacks such as a second surgical site with complications, limited quantity and possible immunological reactions. Human mesenchymal stem cells from bone marrow or adipose tissue have a great potential for bone regeneration. Significant growth opportunities exist for synthetic biomaterials in association with mesenchymal stem cells as bone tissue engineered substitutes.
The objectives of REBORNE is to perform multi-centre clinical trials using advanced biomaterials and cells from autologous or allogeneic sources. Five clinical trials in orthopedic and maxillofacial surgery will take place in 12 clinical centers spread over 8 European countries. A large consortium of 24 participants with top world class laboratories, SMEs manufacturing biomaterials, GMP- cells producing facilities and hospitals will collaborate to reach these ambitious clinical targets.
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