Significant Progress in Cancer Imaging
Groundbreaking method offers a fast and cost-effective way to observe abnormal metabolic processes live in the magnetic resonance imaging scanner
de Maissin et al., Angew. Chem. Int. Ed. 2023 (CC-BY-NC)
"We have found a way to produce biological contrast agents simply, quickly, and safely, which even make metabolism visible. This allows us to observe cancer metabolism in real-time, opening up entirely new perspectives for personalized cancer medicine," says lead investigator Dr. Andreas Schmidt, Head of the "Hyperpolarization and Metabolic MRI" research group in the Department of Medical Physics at the Clinic for Radiology, Medical Center - University of Freiburg, Germany.
How Metabolic MRI Works
In MRI, the magnetic properties of molecules are detected. During hyperpolarization, these properties are significantly amplified for a certain period, resulting in a much stronger signal than usual. Biologically, the molecules behave as before. Thus, metabolic processes can be observed non-invasively. "Moreover, this approach is safe, radiation-free, and metabolic MRI only takes a few minutes. These aspects are particularly important for patients requiring regular follow-up examinations," explains co-investigator Dr. Stephan Knecht, Director of MR development with NVivion Imaging Technologies GmbH.
The study results encompass two significant milestones
1. Successful production of highly polarized pyruvate in a biocompatible, aqueous solution. Pyruvate is a common molecule in the body and is involved in central metabolic processes. The team used the innovative SABRE method (Signal Amplification By Reversible Exchange) to enhance the pyruvate signal. This process allows for the production of highly sensitive biological contrast agents in a few minutes, at low cost, and without chemical modification. So far, SABRE has not been efficient enough as a method, and it was not previously possible to produce contrast agents in aqueous solutions with sufficient purity. In contrast, with the currently established method, the production of contrast agents took approximately an hour or longer and was technically very demanding.
2. With the developed highly sensitive biological contrast agents, the conversion of pyruvate into lactate and alanine was successfully demonstrated in an animal model. These conversions in energy metabolism have already been identified as helpful diagnostic markers in previous studies.
The collaboration between the DKTK partner sites (Medical Center - University of Freiburg and University of Freiburg, Klinikum rechts der Isar Munich) and partners in Göttingen (Max Planck Institute for Multidisciplinary Sciences), Kiel (University Medical Center Schleswig-Holstein), Ulm (NVision Imaging Technologies), and Detroit (Wayne State University) has led to this significant progress. "I would like to express my gratitude to all project participants for their valuable collaboration and contribution to this groundbreaking research," concludes Schmidt.
Original publication
Other news from the department science
Most read news
More news from our other portals
See the theme worlds for related content
Topic world Diagnostics
Diagnostics is at the heart of modern medicine and forms a crucial interface between research and patient care in the biotech and pharmaceutical industries. It not only enables early detection and monitoring of disease, but also plays a central role in individualized medicine by enabling targeted therapies based on an individual's genetic and molecular signature.
Topic world Diagnostics
Diagnostics is at the heart of modern medicine and forms a crucial interface between research and patient care in the biotech and pharmaceutical industries. It not only enables early detection and monitoring of disease, but also plays a central role in individualized medicine by enabling targeted therapies based on an individual's genetic and molecular signature.