Healing the brain: Hydrogels enable neuronal tissue growth
Brain growth may be the stuff of science fiction, but a cross-disciplinary team of researchers has made a step towards it
Synthetic hydrogels were shown to provide an effective scaffold for neuronal tissue growth in areas of brain damage, providing a possible approach for brain tissue reconstruction.

Symbolic image
Computer-generated image
While growing brains may sound like something out of a science fiction movie, a cross-disciplinary team of researchers at Hokkaido University have made a step in that direction. They used hydrogel materials, in combination with neural stem cells, to grow new brain tissue. This is important since, when tissue in our brain is damaged, the neuronal tissue does not have the same regenerative capacity as other parts of our body such as skin.
The first step for researchers was to develop a hydrogel material in which neural stem cells could survive. They found that a neutral gel made with equal parts positively and negatively charged monomers resulted in the best cell adhesion. Researchers then adjusted the ratios of crosslinker molecules to achieve a stiffness similar to that of brain tissue; pores were then created in the gel in which cells could be cultured.
“When I saw the 3D structure of the porous hydrogels that my colleague Tomáš showed in a meeting, I thought they could be utilized in regenerative treatments as a scaffold for growing nerve cells,” recalled lead author Satoshi Tanikawa.
Once the gels were optimized, they were soaked in a growth factor serum to encourage blood vessel growth, and then implanted in damaged areas of the brain in a mouse model. After three weeks, researchers found that immune cells and neuronal cells from the surrounding host brain tissue had entered the hydrogel and that blood vessels had grown.
At this point, researchers injected neural stem cells into the hydrogel. After 40 days, stem cell survival rate was high, and some had differentiated into new astrocyte cells or neuronal cells. It was observed that host cells infiltrated the hydrogel, while some new neuronal cells from the hydrogel migrated to the surrounding brain tissue, showing some degree of integration between the hydrogel and host brain tissue.
The stepwise nature of the process was key, as implanting the hydrogel and transplanting the neural stem cells at the same time proved unsuccessful. This study marks an important step toward developing therapies involving brain tissue regeneration; the next steps involve studying the optimal transplant timing and the effect of the inflammatory response on transplanted cells.
“Conditions affecting blood vessels in the brain, such as cerebral infarction, are a major disease,” commented Tanikawa. “They not only have a high mortality rate but those that survive struggle with severe after-effects. I think this research will become the foundation for medical treatments that could help such patients.”
Original publication
Other news from the department science

Get the life science industry in your inbox
By submitting this form you agree that LUMITOS AG will send you the newsletter(s) selected above by email. Your data will not be passed on to third parties. Your data will be stored and processed in accordance with our data protection regulations. LUMITOS may contact you by email for the purpose of advertising or market and opinion surveys. You can revoke your consent at any time without giving reasons to LUMITOS AG, Ernst-Augustin-Str. 2, 12489 Berlin, Germany or by e-mail at revoke@lumitos.com with effect for the future. In addition, each email contains a link to unsubscribe from the corresponding newsletter.
More news from our other portals
Last viewed contents

Single hepatitis E mutation renders sofosbuvir therapy ineffective - A single mutation stands in the way of a drug's effectiveness. Understanding it helps find new therapeutic approaches

SARS-CoV-2 infects sustentacular cells in the olfactory epithelium of COVID-19 patients - The coronavirus does not appear to infect nerve cells in the olfactory epithelium and in the olfactory bulb
